Iranian Journal of Immunology

KIR Gene Content Does Not Contribute to Susceptibility to Graves’ Disease

Document Type : Original Article

Authors

Elham Ashouri 1
Mohammad Hossein Dabbaghmanesh 1
Amirhossein Hadaegh 2
Soodeh Rowhanirad 1
Marizeh Bakhshayeshkaram 1
Gholamhossein Ranjbar Omrani 1

1 Endocrinology and Metabolism Research Center

2 Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

https://doi.org/10.22034/iji.2013.16824
Abstract
Background: Killer cell immunoglobulin-like receptors (KIR) are expressed on NK cells and a subset of T cells. The variable KIR receptors along with their ligands, HLA class I, influence risk for autoimmune and malignant diseases.
Objective: To investigate the KIR gene profiles in relation to susceptibility to Graves’ disease in patients with ophthalmopathy.
Methods: KIR genes profiles were analyzed in 90 patients presenting Graves’ disease with ophthalmopathy representing upper eyelid retraction, swelling, redness, conjunctivitis, and bulging eyes and were compared with the KIR gene profiles of 112 healthy controls. The presence and absence of 11 variable KIR genes were characterized using a gene-specific PCR typing system.
Results: There was no significant difference in the distribution of KIR gene profiles between patients and controls.
Conclusion: Our data show that none of the KIR genotypes contribute in susceptibility to Graves’ disease; although the role of HLA ligand remains to be characterized.

Keywords

Graves’ Disease
KIR Gene
PCR-SSP
Iranian Journal of Immunology
Volume 10, Issue 3
Summer 2013
Pages 150-157

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