Iranian Journal of Immunology

IL-23 Receptor Gene rs7517847 and rs1004819 SNPs in Ulcerative Colitis

Document Type : Original Article

Authors

Mohammad Mahdi Hayatbakhsh 1
Mohammad Javad Zahedi 1
Mohsen Shafiepour 1
Amin Reza Nikpoor 2
Mojgan Mohammadi 3, 2

1 Department of Gastroenterology, Afzalipour Hospital

2 Department of Microbiology, Virology and Immunology, Medical School, Kerman University of Medical Sciences, Kerman, Iran

3 Physiology Research Centre

https://doi.org/10.22034/iji.2012.16864
Abstract
Background: Crohn’s disease (CD) and ulcerative colitis (UC) are two major clinical presentations of inflammatory bowel disease (IBD). Many novel candidate genes have been found to be associated with increased risk for IBD. Recently IL-23 receptor gene is identified as an IBD associated gene in genome-wide studies.
Objective: To ascertain whether rs7517847 and rs1004819 SNPs in the IL-23 receptor gene are associated with UC in our population in Kerman, south east of Iran.
Methods: A total of 85 patients with UC and 100 healthy controls enrolled in our study. Endoscopic procedure was performed for all patients to determine their disease severity. IL-23 receptor genotyping at positions rs7517847 and rs1004819 was done by PCR-RFLP technique.
Results: The results of this study showed no association between the studied polymorphisms in the IL-23 receptor gene and UC in our population. However, we found a significant association between rs7517847 gene polymorphism in IL-23 receptor and two important clinical variables including blood in stool and bowel movements in UC patients.
Conclusion: The rs7517847 gene polymorphism in IL-23R may be related to the presence of blood in stool and bowel movements in patients with UC. Further functional analysis with other known IL-23 receptor genotypes and/or other candidate genes is necessary to confirm any genetic association with UC in our population.

Keywords

IL-23R
rs7517847
rs1004819
Ulcerative colitis
Iranian Journal of Immunology
Volume 9, Issue 2
Spring 2012
Pages 128-135

Home

Guide for Authors

Submit Manuscript

Guide for Reviewers

Contact Us