Background: Patients with ulcerative colitis are at increased risk of inflammation. Interleukin 23 (IL-23) is a newly identified cytokine with increased expression in inflamed biopsies of colon mucosa in patients with Crohn's disease; however, there is inconsistent evidence on its role in ulcerative colitis. Objective: We aimed to compare serum IL-23 level in patients with ulcerative colitis and normal controls and determine if serum IL-23 level increases with the severity of disease according to endoscopic findings. Methods: We quantified serum IL-23 levels from 60 patients with ulcerative colitis and 20 control individuals. All patients underwent endoscopic procedure to define the severity of disease. Patients were then stratified into 2 groups of "Mild" and "Severe" according to the endoscopic findings. Results: For comparison of serum IL-23 levels, Platelet count, ESR and CRP between the groups, Mann-Whitney U test and independent sample t test were employed, as appropriate. Pearson’s and spearman's correlation tests were employed to test the association of IL-23 with platelet count, CRP and ESR in patients. Our findings showed that serum IL-23 levels were increased in patients with ulcerative colitis compared to normal control. Moreover, patients in "Severe" group had higher serum IL-23 levels and ESR compared with those in "Mild" group. There was no significant sexual dimorphism in any of studied variables. Conclusion: We suggest that IL-23 plays an important role in the p
Mohammadi, M., Hayatbakhsh, M. M., Zahedi, M. J., Jalalpour, M. R. & Pakgohar, A. (2011). Serum Interleukin-23 Levels in Patients with Ulcerative Colitis. Iranian Journal of Immunology, 8(3), 183–188. https://doi.org/10.22034/iji.2011.17024
MLA
Mohammadi, M., Hayatbakhsh, M. M., Zahedi, M. J., Jalalpour, M. R., & Pakgohar, A. "Serum Interleukin-23 Levels in Patients with Ulcerative Colitis", Iranian Journal of Immunology, 8, 3, 2011, 183–188. doi: 10.22034/iji.2011.17024
HARVARD
Mohammadi, M., Hayatbakhsh, M. M., Zahedi, M. J., Jalalpour, M. R., & Pakgohar, A. (2011). 'Serum Interleukin-23 Levels in Patients with Ulcerative Colitis', Iranian Journal of Immunology, 8(3), pp. 183–188. doi: 10.22034/iji.2011.17024
CHICAGO
Mohammadi, M., Hayatbakhsh, M. M., Zahedi, M. J., Jalalpour, M. R. & Pakgohar, A., "Serum Interleukin-23 Levels in Patients with Ulcerative Colitis." Iranian Journal of Immunology, 8 3 (2011): 183–188, doi: 10.22034/iji.2011.17024
VANCOUVER
Mohammadi M., Hayatbakhsh M. M., Zahedi M. J., Jalalpour M. R., Pakgohar A. Serum Interleukin-23 Levels in Patients with Ulcerative Colitis. Iran.J.Immunol. 2011;8(3):183–188. doi: 10.22034/iji.2011.17024
