Background: Human cornea expresses functional Fas-ligand capable of killing Fas+ activated lymphocytes. Fas expression is partly regulated by -670 A/G polymorphism in the promoter region of Fas gene. Objective: The aim of the present study is to determine the association between Fas-670A/G polymorphism and survival of corneal transplantation. Methods: In 276 graft recipients who mainly underwent penetrating keratoplasty because of keratoconus, bullous keratopathy and corneal opacity, Fas -670 A/G polymorphism was determined by allele specific oligonucleotide polymerase chain reaction (ASO-PCR) techniques. Results: There was no statistically significant relationship between Fas -670 A/G polymorphism and rejection episode (p=0.35). Moreover, the relationship between this polymorphism and rejection episode outcome (transplant recovery vs failure) was not statistically significant (p=0.13). Conclusion: The results of the present study show no significant correlation between corneal graft rejection, rejection recovery and Fas -670A/G gene polymorphism.
Jahadi Hosseini, H. R., Kamali Sarvestani, E., Akbari, M. & Mosallaei, M. (2009). Effect of Fas -670 A/G Gene Polymorphism on Corneal Allograft Endothelial Rejection. Iranian Journal of Immunology, 6(1), 28–32. https://doi.org/10.22034/iji.2009.17070
MLA
Jahadi Hosseini, H. R., Kamali Sarvestani, E., Akbari, M., & Mosallaei, M. "Effect of Fas -670 A/G Gene Polymorphism on Corneal Allograft Endothelial Rejection", Iranian Journal of Immunology, 6, 1, 2009, 28–32. doi: 10.22034/iji.2009.17070
HARVARD
Jahadi Hosseini, H. R., Kamali Sarvestani, E., Akbari, M., & Mosallaei, M. (2009). 'Effect of Fas -670 A/G Gene Polymorphism on Corneal Allograft Endothelial Rejection', Iranian Journal of Immunology, 6(1), pp. 28–32. doi: 10.22034/iji.2009.17070
CHICAGO
Jahadi Hosseini, H. R., Kamali Sarvestani, E., Akbari, M. & Mosallaei, M., "Effect of Fas -670 A/G Gene Polymorphism on Corneal Allograft Endothelial Rejection." Iranian Journal of Immunology, 6 1 (2009): 28–32, doi: 10.22034/iji.2009.17070
VANCOUVER
Jahadi Hosseini H. R., Kamali Sarvestani E., Akbari M., Mosallaei M. Effect of Fas -670 A/G Gene Polymorphism on Corneal Allograft Endothelial Rejection. Iran.J.Immunol. 2009;6(1):28–32. doi: 10.22034/iji.2009.17070
