Volume 18 (2021)
Volume 17 (2020)
Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)
Original Article
1. The Efficiency of CD40 Down Regulation by siRNA and Antisense ODN: Comparison of Lipofectamine and FuGENE6

Padideh Ebadi; Mohammad Hossein Karimi; Ali Akbar Pourfathollah; Saheb Ghadam Lotfi; Zahra Soheila Soheili; Shahram Samiee; Smerdis Hajati; Fatemeh Nadali; Bita Geramizadeh; Seyyed Mohammad Moazzeni

Volume 6, Issue 1 , Winter 2009, Pages 1-11

  Background: Dendritic cells (DCs) are ideal accessory cells in the field of gene therapy. Delivery of DNA and siRNA into mammalian cells is a useful technique in treating various diseases caused by single gene defects. Selective gene silencing by small interfering RNAs (siRNAs) and antisense oligodeoxynucleotides ...  Read More

Original Article
2. Immunogencity of HSA-L7/L12 (Brucella abortus Ribosomal Protein) in an Animal Model

Iraj Pakzad; Abbas Rezaee; Mohammad Javad Rasaee; Bahman Tabbaraee; Ali Delpisheh

Volume 6, Issue 1 , Winter 2009, Pages 12-21

  Background: The immunogenic Brucella abortus ribosomal protein L7/L12 is a promising candidate antigen for the development of subunit vaccines against brucellosis. Objective: This study was aimed to evaluate the protection of recombinant Human Serum Albumin (HAS)-L7/L12 fusion protein in Balb/c mice. ...  Read More

Original Article
3. Kinetics of Primary and Memory Cytotoxic T Lymphocyte Responses to Herpes Simplex Virus 1 Infection: Granzyme B Mediated CTL Activity

Masumeh Gorgian Mohammadi; Taravat Bamdad; Masoud Parsania; Hamid Reza Hashemi; Somayeh Puyanfard

Volume 6, Issue 1 , Winter 2009, Pages 22-27

  Background: Herpes simplex virus type 1 is one of the most common viruses among human population. Studies demonstrate the essential role of cell mediated immunity, especially CD8+ T cells, in prevention and clearance of HSV1. Objective: It is of great importance to improve our knowledge about the kinetics ...  Read More

Original Article
4. Effect of Fas -670 A/G Gene Polymorphism on Corneal Allograft Endothelial Rejection

Hamid Reza Jahadi Hosseini; Eskanadar Kamali Sarvestani; Mitra Akbari; Mahnaz Mosallaei

Volume 6, Issue 1 , Winter 2009, Pages 28-32

  Background: Human cornea expresses functional Fas-ligand capable of killing Fas+ activated lymphocytes. Fas expression is partly regulated by -670 A/G polymorphism in the promoter region of Fas gene. Objective: The aim of the present study is to determine the association between Fas-670A/G polymorphism ...  Read More

Original Article
5. The Influence of Iron Loading and Iron Chelation on the Proliferation and Telomerase Activity of Human Peripheral Blood Mononuclear Cells

Bahram Bagherpour; Marjan Gharagozloo; Behjat Moayedi

Volume 6, Issue 1 , Winter 2009, Pages 33-39

  Background: Iron is an essential trace element in cell proliferation. Several investigations demonstrate that iron deprivation inhibits cell proliferation. However, the impact of iron on telomerase activity of activated lymphocytes remains unexplained to date. Objective: In this study, the effect of ...  Read More

Original Article
6. Age Specific Reference Levels of Serum Prostate-Specific Antigen, Prostate Volume and Prostate Specific Antigen Density in Healthy Iranian Men

Abdol Aziz Khezri; Mehdi Shirazi; Seyyed Mohammad Taghi Ayatollahi; Mehrzad Lotfi; Mehrdad Askarian; Ali Ariafar; Mohammad Amin Afrasiabi

Volume 6, Issue 1 , Winter 2009, Pages 40-48

  Background: It is relevant to highlight that there is not a precise and perfect report on either 95 percentile value (upper limit of normal range) or on appropriate reference intervals for serum PSA in Iranian population. Objective: To determine age-specific reference ranges for serum prostate-specific ...  Read More

Short Paper
7. Distribution of HLA-B*27 Alleles in Pa-tients with Ankylosing Spondylitis in Iran

Salomeh Fouladi; Minoo Adib; Mansoor Salehi; Hadi Karimzadeh; Zahra Bakhshiani; Vajiheh Ostadi

Volume 6, Issue 1 , Winter 2009, Pages 49-54

  Background: HLA-B*27 is strongly associated with ankylosing spondylitis (AS). It represents a family of alleles that differ among ethnic groups. Objective: The aim of this study was to determine the distribution of HLA-B*27 alleles in AS patients and healthy controls in Isfahan (Iran). Methods: Sixty ...  Read More