Background: Despite advances in the medical care of renal transplant recipients which have led to an improvement in allograft survival, renal allograft rejection is still a major ob-stacle to successful organ transplantation. Understanding the mechanisms contributing to allograft rejection will be of great importance for the development of efficient antirejection strategies. Objective: The aim of current investigation was to study the impact of polymor-phisms of CCR5Δ32, CCR5- 59029 A/G and CCR2-V64I on renal allograft survival. Methods: Using PCR and PCR-RFLP methods in 84 renal transplant recipients, the influ-ence of CCR5Δ32, CCR5- 59029 A/G and CCR2-V64I polymorphisms on renal allograft survival in two rejector and non-rejector groups were examined. Rejector group was de-fined as having rejection before 1 year and non-rejector group had stable graft function at least for 5 years. Results: Significant reductions were found in the risk of renal transplant rejection in recipients possessing the CCR2-64I (A) allele (p=0.03) or 59029-A allele (p=0.03) compared to non-rejector group. There were no significant differences in the fre-quency of CCR5Δ32 polymorphism in rejector group compared to non-rejector group (p>0.05). Conclusion: It was possible to conclude that the chemokine receptors CCR2-V64I (A) and CCR5- 59029 A alleles may influence renal allograft survival.
Omrani, M. D., Mokhtari, M. R., Tagizadae, A., Bagheri, M. & Ahmad-Poor, P. (2008). Association of CCR5-59029 A/G and CCR2-V64I Variants with Renal Allograft Survival. Iranian Journal of Immunology, 5(4), 201–206. https://doi.org/10.22034/iji.2008.17168
MLA
Omrani, M. D., Mokhtari, M. R., Tagizadae, A., Bagheri, M., & Ahmad-Poor, P. "Association of CCR5-59029 A/G and CCR2-V64I Variants with Renal Allograft Survival", Iranian Journal of Immunology, 5, 4, 2008, 201–206. doi: 10.22034/iji.2008.17168
HARVARD
Omrani, M. D., Mokhtari, M. R., Tagizadae, A., Bagheri, M., & Ahmad-Poor, P. (2008). 'Association of CCR5-59029 A/G and CCR2-V64I Variants with Renal Allograft Survival', Iranian Journal of Immunology, 5(4), pp. 201–206. doi: 10.22034/iji.2008.17168
CHICAGO
Omrani, M. D., Mokhtari, M. R., Tagizadae, A., Bagheri, M. & Ahmad-Poor, P., "Association of CCR5-59029 A/G and CCR2-V64I Variants with Renal Allograft Survival." Iranian Journal of Immunology, 5 4 (2008): 201–206, doi: 10.22034/iji.2008.17168
VANCOUVER
Omrani M. D., Mokhtari M. R., Tagizadae A., Bagheri M., Ahmad-Poor P. Association of CCR5-59029 A/G and CCR2-V64I Variants with Renal Allograft Survival. Iran.J.Immunol. 2008;5(4):201–206. doi: 10.22034/iji.2008.17168
