Iranian Journal of Immunology

Association between HLA-DRB1*01 and HLA-Cw*08 and Outcome Following HTLV-I Infection

Document Type : Original Article

Authors

Houshang Rafatpanah 1, 2
Vera Pravica 3
Reza FaridHosseini 1
Abbas Tabatabaei 4
Wiliam Ollier 2
Kay Poulton 5
Wendy Thomson 6
Ian Hutchinson 3

1 Immunology Research Center, BuAli Research Institute, Mashhad University of Medical Sciences, Iran

2 Center for Integrated Genomic Medical Research, The University of Manchester, Manchester, UK

3 Immunology Research Group, Faculty of Life sciences, The University of Manchester, UK

4 Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

5 Transplantation Laboratory, Central Manchester, Healthcare Trust, Manchester, UK

6 ARC Epidemiology Unit, The University of Manchester, Manchester, UK

https://doi.org/10.22034/iji.2007.17185
Abstract
Background: Human T cell lymphotropic virus type I (HTLV-I)-associated myelopa-thy/tropical spastic paraparesis (HAM/TSP) is an inflammatory disease which occurs in less than 2% of HTLV-I -infected individuals. High proviral load, high HTLV-I-specific CD8+ cytotoxic T lymphocyte frequency (CTL) and host genetic factors such as HLA all appear to be associated with HTLV-I infection. Previous studies have shown that HLA-DRB1*01 increases the risk of HAM/TSP in Japanese HTLV-I infected individu-als.
Objective: To investigate the association between HLA class II DRB1 alleles and HLA class I alleles (HLA-Cw*08, B54, A*02 and A-30) in HTLV-I infected individu-als in Mashhad.
Methods: Here we determined the frequency of HLA class II DRB1, using INNO-LIPA reverse hybridization line probe assay, and HLA class I alleles (HLA-Cw*08,B54, A*02 and A-30) by PCR-SSCP method in healthy controls, HAM/TSP patients and HTLV-I infected individuals born and resident in Mashhad.
Results: The frequency of HLA-DRB1*01 alleles in this population was different from other areas of Iran. The frequency of HLA-DRB1*01 was significantly increased in HAM/TSP patients compared with carriers (p 0.028; OR=9.4). The frequency of HLA-Cw*08 was also significantly increased in HAM/TSP patients compared with controls (p=0.03; OR=13.5).
Conclusion: Our results may suggest that possession of HLA-DRB1*01 increases the risk of HAM/TSP in HTLV-I-infected individuals and HLA-Cw*08 correlates with low CTL immune response in HAM/TSP patients.

Keywords

HLA
HTLV-I
HAM/TSP
Iranian Journal of Immunology
Volume 4, Issue 2
Spring 2007
Pages 94-100

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