Iranian Journal of Immunology

T Regulatory Cells Frequency During Maintenance Phase Chemotherapy for Pediatric Acute Lymphoblastic Leukemia

Document Type : Short Paper

Authors

Marina Nayeli Medina-Rosales 1
Susana Godina-Gonzalez 2
Mariana Haydee Garcia-Hernandez 1

1 Unidad de Investigación Biomédica de Zacatecas. Delegación Zacatecas, Instituto Mexicano del Seguro Social, IMSS, México

2 Facultad de Ciencias Qumicas, Universidad Autónoma de Zacatecas, UAZ, México

https://doi.org/10.22034/iji.2020.80297
Abstract
Background: Drugs used in cancer treatment specifically kill T regulatory cells. Objective: To determine different phenotypes of T regulatory cells during the maintenance phase chemotherapy for pediatric acute lymphoblastic leukemia (ALL). Materials: We evaluated the percentages of regulatory T cells by flow cytometry. Soluble CTLA-4 (sCTLA-4) in plasma was evaluated by ELISA assay. Results: Increased percentages of CD4+CD25+ T cells, CD4+CD39+ T cells, CD4+Foxp3+ T cells, and CD4+CD25High T cells were observed in children with ALL in comparison to healthy controls. In addition, the ALL patients with >12 months of therapy showed increased CD4+CD39+ T cells compared to the ALL patients with ≤12 months and healthy controls. Similarly, the CD4+CD25+ T cells and CD4+Foxp3+ T cells increased according to maintenance therapy time. Conclusion: Our results showed increased percentages of regulatory T cells in pediatric ALL patients despite chemotherapy, which might be compromising the anti-leukemic cellular immune response.

Keywords

Acute Lymphoblastic Leukemia
ALL
Chemoterapy
Pedriatic
T Regulatory Cells
Iranian Journal of Immunology
Volume 17, Issue 1
Winter 2020
Pages 87-93

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