Volume 19 (2022)
Volume 18 (2021)
Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)
Original Article
1. Th1/Th2 Imbalance and Elevated PD-L1 in Pleural Effusion Predict the Risk of Multi-Drug Resistant Tuberculous Pleuritis

Hongyan Xu; Yueqing Yang; Qianhong Wu; Yan Zhang

Volume 17, Issue 1 , March 2020, Pages 1-13


  Background: Patient immune status might be indicative of the variance in bacterial genetics in drug-resistant tuberculous pleuritis and could be used for predicting the risk of multi-drug resistant tuberculous pleuritis (MDR-TB). Objective: To determine the significance of Th2/Th1 ratio and concentration ...  Read More

Original Article
2. TLR agonist rHP-NAP as an Adjuvant of Dendritic Cell-Based Vaccine to Enhance Anti-Melanoma Response

Meiling Hou; Xiaodong Wang; Jike Lu; Xun Guo; Cong Ding; Taotao Liang; Zhenyu Ji; Peng Xie; Xin Liu; Qiaozhen Kang

Volume 17, Issue 1 , March 2020, Pages 14-25


  Background: Melanoma is a common and malignant cutaneous tumor, which is responsible for a large proportion of skin cancer deaths. Dendritic cell (DC)-based vaccines have achieved positive results in the treatment of melanoma because of their ability to induce cytotoxic response to facilitate tumor elimination. ...  Read More

Original Article
3. Effect of Cytomegalovirus Recombinant Phosphoprotein 150 (pp150) on Function and Maturation of Murine Dendritic Cells: an In-Vitro Study

Yousef Nikmanesh; Shohreh Shahmahmoodi; Ramin Yaghobi; Sayed Mahdi Marashi; Mahmood Mahmoudi; Mahdokht Hossein Aghdaie; Maryam Khosravi; Mohammad Hossein Karimi

Volume 17, Issue 1 , March 2020, Pages 26-40


  Background: Tegument protein pp150 of cytomegaloviruses (CMVs) plays a vital role in all stages of viral life cycle, representing the most important tegument protein candidate for HCMV treatment. However, the exact role of pp150 in immune regulation is yet to be elucidated. Objective: To examine the ...  Read More

Original Article
4. Activity of Dipeptidyl Peptidase-IV/CD26 and Aminopeptidase N/CD13 in Secretome of Mesenchymal Stem Cells after Treatment with LPS and PMA

Khadijeh Ramezani Ali Akbari; Anwar Fathollahi; Seyed Mahmoud Hashemi; Ramin Pouriran; Farshid Yeganeh

Volume 17, Issue 1 , March 2020, Pages 41-51


  Background: Emerging evidence suggests that secretome of mesenchymal stem cells has many anti-inflammatory and regenerative properties, which makes it a suitable candidate for the treatment of autoimmune and degenerative diseases. Dipeptidyl Peptidase-IV (DPP-IV)/CD26 and Aminopeptidase N (APN)/CD13 ...  Read More

Original Article
5. The Immunomodulatory Effects and Mechanisms of Tim-3 Action in the Early Stage of Mice with Severe Acute Pancreatitis

Min Lin; Jin Huang; Wei-Chang Chen; Zhi-Ning Fan; Xihu Qin

Volume 17, Issue 1 , March 2020, Pages 52-63


  Background: Tim-3 has been considered as an ideal target for the immunotherapy of inflammation, but it is unclear whether Tim-3 also plays an important role in acute pancreatitis (AP), as well. Objective: To identify the immunomodulatory effects and mechanisms of Tim-3 action in the early stages of severe ...  Read More

Original Article
6. Effect of Tribulus Terrestris L. on Expression of ICAM-1, VCAM-1, E-Selectin and Proteome Profile of Human Endothelial Cells In-Vitro

Elahe Amirinezhad Fard; Zahra Fereydouni; Kamran Mansouri; Ali Mostafaie

Volume 17, Issue 1 , March 2020, Pages 64-74


  Background: Atherosclerosis is a chronic inflammation that interferes with blood arteries functions due to the accumulation of low density lipids and cholesterol. Objective: To investigate the effect of aqueous extract and saponin fraction of Tribulus terrestris L. (TT) on the proteome and expression ...  Read More

Original Article
7. Protective Potential of Conjugated P. aeruginosa LPS –PLGA Nanoparticles in Mice as a Nanovaccine

Leila Safari Zanjani; Reza Shapoury; Mehrouz Dezfulian; Mehdi Mahdavi; Mehdi Shafieeardestani

Volume 17, Issue 1 , March 2020, Pages 75-86


  Background: Pseudomonas aeruginosa has an important role in nosocomial infections. Objective: To evaluate biological activity of the detoxified LPS (D-LPS) entrapped into Poly lactic-co-glycolic acid (PLGA) nanoparticles. Materials: LPS was extracted and detoxified from the P. aeruginosa strain PAO1. ...  Read More

Short Paper
8. T Regulatory Cells Frequency During Maintenance Phase Chemotherapy for Pediatric Acute Lymphoblastic Leukemia

Marina Nayeli Medina-Rosales; Susana Godina-Gonzalez; Mariana Haydee Garcia-Hernandez

Volume 17, Issue 1 , March 2020, Pages 87-93


  Background: Drugs used in cancer treatment specifically kill T regulatory cells. Objective: To determine different phenotypes of T regulatory cells during the maintenance phase chemotherapy for pediatric acute lymphoblastic leukemia (ALL). Materials: We evaluated the percentages of regulatory T cells ...  Read More