Iranian Journal of Immunology

Importance of MMP-8 in Salivary and Gingival Crevicular Fluids of Periodontitis Patients

Document Type : Short Paper

Authors

Kazem Fatemi 1
Seyed Abdolrahim Rezaee 2
Seyed Ali Banihashemrad 3
Sanaz Keyvanfar 4
Meghdad Eslami 3

1 Department of periodontology, Faculty of dentistry, Mashhad university of medical science, Mashhad, Iran.

2 Department of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad , Iran.

3 Department of Periodontology, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran

4 Department of periodontology, faculty of dentistry, Birjand University of Medical Sciences, Birjand, Iran. Dentistry Clinical Research Development Center, Birjand University of medical science, Birjand, Iran

https://doi.org/10.22034/iji.2020.81170.1512
Abstract
Background: Matrix metalloproteinases (MMPs) stimulate alveolar bone loss in chronic periodontitis. Objective: To evaluate the salivary and gingival crevicular fluid (GCF) levels of MMP-8 in patients with moderate to severe chronic periodontitis. Methods: 42 participants were divided into two groups: a case group (21 patients with generalized moderate to severe chronic periodontitis) and a control group (21 healthy periodontal subjects). GCF and saliva samples were obtained from both groups. Salivary and GCF MMP-8 levels of each subject were detected using the ELISA method. Results: Mean±SD values of salivary MMP-8 levels of the control and case groups were 1.52 ± 0.65 ng/ml and 6.06 ± 1.18 ng/ml, respectively, and statistically significant difference was observed (p=0.0001). Also, mean±SD values of GCF MMP-8 levels of the control and case groups were 0.87 ± 0.26 ng/ml and 2.92 ± 0.64 ng/ml, respectively; which was statistically significant (p=0.0001). Conclusion: Our results demonstrate an increased concentration of salivary and GCF levels of MMP-8 in the patient group.

Keywords

Chronic Periodontitis
Crevicular Fluid
Gingiva
Matrix Metalloproteinase-8
Saliva
Iranian Journal of Immunology
Volume 17, Issue 3
Summer 2020
Pages 236-243

Home

Guide for Authors

Submit Manuscript

Guide for Reviewers

Contact Us