Iranian Journal of Immunology

Maternal Cold-Reacting Immunoglobulin G Anti-M of MNS Blood Group System Causing Hemolytic Disease of the Fetus

Document Type : Case Report

Authors

Yan-Lian Liang 1
Yu Shi 2
Yu-Qing Su 1
Fan Wu 1
Yanwen Liang 3
Xiuchu Fan 3
Jiansuo Lin 3
Yi Liu 4
Long Peng 1
Jianwei Ren 5
Shuang Liang 1

1 Shenzhen Institute of Transfusion Medicine, Shenzhen Blood Center, Shenzhen, Guangdong, China.

2 Department of Biomedical Sciences, City University of Hong Kong, Hong Kong SAR, China.

3 R&D Division, Shenzhen Ritzcon Biological Technology Co., Ltd., Shenzhen, Guangdong, P.R.China.

4 Guangdong Key Laboratory for Research and Development of Natural Drugs, Department of Pharmacology, Marine Medicine Research Institute, Guangdong Medical University, Zhanjiang, Guangdong, P.R.China.

5 Department of Biomedical Sciences, City University of Hong Kong, Hong Kong SAR, China. R&D Division, Shenzhen Ritzcon Biological Technology Co., Ltd., Shenzhen, Guangdong, P.R.China. Centre for Regenerative Medicine and Health, Hong Kong Institute of Science & Innovation, Chinese Academy of Sciences, Hong Kong SAR, P.R.China.

https://doi.org/10.22034/iji.2023.93993.2273
Abstract
Several cases of the hemolytic disease of the fetus and newborn (HDFN) caused by immunoglobulin G (IgG) anti-M antibodies have been reported, in which almost all the HDFN-associated anti-M were warmly reacting. Here we report two cases of severe HDFN associated with cold-reacting IgG anti-M. In both cases, pregnancy was terminated, in weeks 33 and 23 respectively, due to a diagnosis of fetal growth retardation (FGR). To our knowledge, these are the most severe HDFN cases caused by cold-reacting IgG anti-M.

Keywords

Anti-M Antibody
Cold-reacting IgG
HDFN
MNS Blood Group
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Iranian Journal of Immunology
Volume 20, Issue 1
Winter 2023
Pages 129-134

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