Volume 21 (2024)
Volume 19 (2022)
Volume 18 (2021)
Volume 17 (2020)
Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)
Review Article
Vaccine Adjuvants: Selection Criteria, Mechanism of Action Associated with Immune Responses and Future Directions

Arslan Habib; Khalid Mahmood Anjum; Riffat Iqbal; Ghulam Jaffar; Zeeshan Ashraf; Malik ShahZaib Khalid; Muhammad Usman Taj; Syeda Wafa Zainab; Muhammad Umair; Muhammad Zohaib; Tabinda Khalid

Volume 20, Issue 1 , March 2023, Pages 1-15


  The most effective method to minimize the prevalence of infectious diseases is vaccination. Vaccines enhance immunity and provide protection against different kinds of infections. Subunit vaccines are safe and less toxic, but due to their lower immunogenicity, they need adjuvants to boost the immune ...  Read More

Original Article
Activation of β2-adrenergic Receptor Alleviates Collagen-induced Arthritis by Ameliorating Th17/Treg Imbalance

Jian-Hua Lu; Xiao-Xiao Rui; Ting-Ting Wang; Xiao-Qin Wang; Yu-Ping Peng; Yi-Hua Qiu

Volume 20, Issue 1 , March 2023, Pages 16-25


  Background: Recent research in our laboratory shows that CD4+ T cells express the β2 adrenergic receptor (β2-AR), and the sympathetic neurotransmitter norepinephrine regulates the function of T cells via β2-AR signaling. However, the immunoregulatory effect of β2-AR and its related ...  Read More

Original Article
The Evaluation of the Effect of Tolerogenic Probiotics on the Maturation of Healthy Dendritic Cells versus Immature Dendritic Cells

Maryam Rastin; Mahmoud Mahmoudi; Nafiseh Tabasi; Nadia Kia; Jafar Hajavi; Seyed-Alireza Esmaeili

Volume 20, Issue 1 , March 2023, Pages 26-35


  Background: Dendritic cells, (DCs) as one of the important immune cell populations, are responsible for the initiation, development, and control of acquired immune responses. Myeloid dendritic cells can be used as a vaccine for several autoimmune diseases and cancers. Tolerogenic probiotics with regulatory ...  Read More

Original Article
rMBP-NAP Suppresses OXA-induced Allergic Dermatitis by Regulating the Th1/Th2 Balance

Hao Zheng; Qiaozhen Kang; Chenglong Zhang; Lu Yang; Xin Liu

Volume 20, Issue 1 , March 2023, Pages 36-44


  Background: Allergic dermatitis (AD) is an inflammatory skin disease that arises from abnormal T lymphocyte activation. A recombinant fusion protein comprising Helicobacter pylori neutrophil-activating protein and maltose binding protein, rMBP-NAP, has been documented as a novel immunomodulatory TLR ...  Read More

Original Article
Methyl-cpg-binding Domain Protein 2 Silencing Inhibits Th17 Differentiation of CD4+T cells Induced by Ovalbumin

Yan Jiang; Linqiao Li; Qilu Pan; Xiaojing Du; Qian Han; Feixiang Ling; Rou Li; Lin Mai; Jianwei Huang; Shuyuan Chu; Libing Ma

Volume 20, Issue 1 , March 2023, Pages 45-56


  Background: Little is known about MBD2’s epigenetic regulation in the immune pathogenesis of CD4+T cell differentiation.Objective: This study attempted to explore the mechanism of methyl-cpg-binding domain protein 2 (MBD2) in CD4+T cell differentiation stimulated by environmental allergen ovalbumin ...  Read More

Original Article
Immunogenicity of the Non-toxic Form of Staphylococcus Aureus α-Hemolysin Using a Chimeric Fusion in Mice

Liquan Yu; Jian Dai; Ziyao Fan; Liang Chen; Daolong Liu; Zhijun Wu; Hunan Sun; Chunyu Tong; Yongzhong Yu; Baifen Song; Jinzhu Ma; Yudong Cui

Volume 20, Issue 1 , March 2023, Pages 57-66


  Background: Staphylococcus aureus is an opportunistic pathogen responsible for various infections with diverse clinical presentation and severity. The α-hemolysin is a major virulence factor in the pathogenesis of S. aureus infections.Objective: To produce a chimeric fusion protein for hemolytic ...  Read More

Original Article
Exploring the Influence of Hepatitis B Immunoglobulin on the Immune Response to the Hepatitis B Vaccine in a Mouse Model

Tao Wei; Wei-Hong Lv; Mei-Hua Gao; Shan-Juan Tan; Ling Li; Lei Zhang

Volume 20, Issue 1 , March 2023, Pages 67-75


  Background: The extent to which maternal antibodies against the hepatitis B surface antigen (HBsAb) acquired transplacentally affect the immune responses to the hepatitis B vaccine (HBVac) in infants is still uncertain.Objective: To explore the impact of the HBsAb on the immune response to the HBVac ...  Read More

Original Article
Effect of the Previous History of the SARS-CoV-2 Infections on Antibody Levels among Sputnik V Vaccinated Healthcare Workers

Atieh Yaghoubi; Samira Asli; Maryam Parhizkar; Maryam Mohammadpour; Ali Khorsand; Mehdi Yousefi; Taravat Bamdad; Saeid Amel Jamehdar

Volume 20, Issue 1 , March 2023, Pages 76-82


  Background: Measuring the level of antibodies produced post-vaccination in response to the SARS-CoV-2 spike protein is considered a strategy for estimating the effectiveness of the COVID-19 vaccines.Objective: To examine the antibody levels among the healthcare workers in different hospitals in Mashhad, ...  Read More

Short Paper
Methylation Profile of Cancer Testis Antigens in Colorectal Cancer

Nadiah Abu; Nurul Ainaa Adilah Rus Bakarurraini; Siti Nurmi Nasir; Muhiddin Ishak; Rashidah Baharuddin; Rahman Jamal; Nurul Syakima Ab Mutalib

Volume 20, Issue 1 , March 2023, Pages 83-91


  Background: Cancer testis antigens (CTAs) are a class of immune-stimulating antigens often overexpressed in many types of cancers. The usage of the CTAs as immunotherapy targets have been widely investigated in different cancers including melanoma, hematological malignancies, and colorectal cancer. Studies ...  Read More

Original Article
Anti-inflammatory Mechanisms of IL-38 in Chinese Patients with Allergic Rhinitis

Xiaoqiang Wang; Yang Shen; Xia Ke; Suling Hong

Volume 20, Issue 1 , March 2023, Pages 92-103


  Background: T-helper 17 (Th17) cell response is engaged in the onset of allergic rhinitis (AR). Moreover, interleukin (IL)-38 is thought to be involved in inhibiting cytokine secretion in the Th17 pathway.Objective: To evaluate the regulatory function of IL-38 on abnormal Th17 responses in Chinese patients ...  Read More

Original Article
Evaluation of CD137 and CD137L Transcript Levels and the Serum sCD137 in Immune-mediated Polyneuropathy

Shirin Torkestani; Alireza Zamani; Mehrdokht Mazdeh; Elahe Talebi-Ghane; Ghodratoallah Roshanaie; Mohammad Mahdi Eftekharian

Volume 20, Issue 1 , March 2023, Pages 104-113


  Background: Abnormal humoral and cellular immune responses have been reported in immune-mediated polyneuropathies. CD137, as a costimulatory molecule and a TNF receptor superfamily member, has been demonstrated to have a key role in the pathogenesis of many autoimmune as well as inflammatory disorders.Objective: ...  Read More

Original Article
Leukocyte Reduction Filters Are Reliable and Economic Source for Natural Killer Cell Preparation

Moosa Rezwani; Abdulbaset Mazarzaei; Zahra Abbasi-Malati; Ali Akbar Pourfathollah

Volume 20, Issue 1 , March 2023, Pages 114-128


  Background: An issue that hinders researchers’ access to Natural Killer (NK) cells is their low proportion in peripheral blood leukocytes. This issue is currently addressed by methods involving a series of differentiation and expansions that are time-consuming and expensive.Objective: We have investigated ...  Read More

Case Report
Maternal Cold-Reacting Immunoglobulin G Anti-M of MNS Blood Group System Causing Hemolytic Disease of the Fetus

Yan-Lian Liang; Yu Shi; Yu-Qing Su; Fan Wu; Yanwen Liang; Xiuchu Fan; Jiansuo Lin; Yi Liu; Long Peng; Jianwei Ren; Shuang Liang

Volume 20, Issue 1 , March 2023, Pages 129-134


  Several cases of the hemolytic disease of the fetus and newborn (HDFN) caused by immunoglobulin G (IgG) anti-M antibodies have been reported, in which almost all the HDFN-associated anti-M were warmly reacting. Here we report two cases of severe HDFN associated with cold-reacting IgG anti-M. In both ...  Read More

Case Report
Variations in Macrophage Activation Syndrome-associated Cardiac Diseases: A Report on Two Cases

Na Lin; Liping Xu; Qiaoding Dai

Volume 20, Issue 1 , March 2023, Pages 135-143


  Macrophage activation syndrome (MAS), a secondary hemophagocytic lymphohistiocytosis characterized by an excessive systemic inflammatory response, is a life-threatening and rare disease. Cardiovascular damage is a common and severe complication of the disease, however, it is easily ignored and not well ...  Read More