Iranian Journal of Immunology

Abnormal Changes in IL-13 and IL-17A Serum Levels in Children with Adenovirus Pneumonia and their Diagnostic Value

Document Type : Original Article

Authors

Jianbo Jiang 1
Lili Sun 2
Meixia Huang 3

1 Pediatric Department, Hangzhou Fuyang Women and Children Hospital, Zhejiang Province, 311400, China.

2 Obstetric Department, Hangzhou Fuyang Women and Children Hospital, Zhejiang Province, 311400, China.

3 Pediatric Department, Children’s Hospital of Zhejiang University School of Medicine, Zhejiang Province, 310057, China.

https://doi.org/10.22034/iji.2024.99509.2648
Abstract
Background: Human adenovirus (HAdV) is an enveloped icosahedral DNA virus. HAdV infection can lead to immune system damage, resulting in decreased numbers and compromised function of T cells and B cells. It can also cause an imbalanced Th1/Th2 ratio and dysregulation of pro-inflammatory and anti-inflammatory cytokines.
Objective: To investigate the serum levels of interleukin (IL)-13 and IL-17A in children with HAdV pneumonia.
Methods: Pediatric patients diagnosed with HAdV pneumonia were divided into a non-severe group or a severe group based on the severity of their condition. Patients in the severe group were further classified into good and poor prognosis subgroups. We collected 2-2.5 mL of venous blood from each patient, which was then centrifuged. Using an ELISA detection kit, we determined the concentrations of IL-13 and IL-17A.
Results: Patients with a severe condition exhibited significantly higher serum concentrations of IL-13 and IL-17A than the non-severe cases. Out of 50 severe cases, 32 had good prognoses, while 18 cases showed poor prognoses. Patients with poor prognoses showed significantly higher serum concentrations of IL-13 compared to those with good prognoses.
Conclusion: Serum concentrations of IL-13 and IL-17A are potential diagnostic markers for pediatric patients with severe HAdV pneumonia. Additionally, they demonstrate good predictive value for a poor prognosis in severe pneumonia cases.

Keywords

Adenovirus
Interleukin-13
Interleukin-17A
Pediatrics
Severe Pneumonia
Iranian Journal of Immunology
Volume 21, Issue 1
Winter 2024
Pages 81-88

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