Volume 20 (2023)
Volume 19 (2022)
Volume 18 (2021)
Volume 17 (2020)
Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)
Original Article
Comparative Immunogenicity and Neutralization Potency of Four Approved COVID-19 Vaccines in BALB/c Mice

Navid Dashti; Forough Golsaz-Shirazi; Mahmood Jeddi-Tehrani; Amir-Hassan Zarnani; Mohammad Mehdi Amiri; Fazel Shokri

Volume 21, Issue 1 , March 2024, Pages 1-14


  Background: Since the outbreak of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), several vaccine candidates have been developed within a short period of time. Although the potency of these vaccines was evaluated individually, their comparative potency was not comprehensively ...  Read More

Original Article
The Ratio of Peripheral Blood Natural Killer Cells is not a Solid Surrogate Immune Index in Unexplained Recurrent Miscarriage

Niwei Yan; Pingyin Lee; Huiying Jie; Canquan Zhou; Yuan Yuan

Volume 21, Issue 1 , March 2024, Pages 15-26


  Background: Immunotherapies targeting peripheral natural killer (pbNK) cells in unexplained recurrent miscarriage (uRM) remain controversial. We hypothesized that the change in pbNK cell count might be a result of innate immune responses rather than a cause.Objective: To explore whether the pbNK count ...  Read More

Original Article
Immunohistochemical Evaluation of NKP46 Receptor Expression and the Number of NK Cells in the Endometrium of Patients with Endometriosis

Mahdi Alimoradi Fard; Mehri Ghafourian; Abdolah Mousavi-Salehi; Farideh Moramazi; Nastaran Ranjbari

Volume 21, Issue 1 , March 2024, Pages 27-36


  Background: Endometriosis is a medical condition that can cause infertility in women. Women with endometriosis experience a decrease in NK cell cytotoxic activity against endometrial cells, ultimately contributing to the spread of these cells.Objective: To assess the frequency of NK cells and the expression ...  Read More

Original Article
Sulforaphane Regulates Macrophage M1/M2 Polarization to Attenuate Macrophage-induced Caco-2 Cell Injury in an Inflammatory Environment

Ting Yi; Zhiyin Liu; Haokun Jia; Qiongzhi Liu; Jianjiao Peng

Volume 21, Issue 1 , March 2024, Pages 37-52


  Background: The imbalance between M1 and M2 macrophage activation is closely associated with the pathogenesis of inflammatory bowel diseases (IBDs). Sulforaphane (SFN) plays an important role in the treatment of inflammatory diseases.Objective: To investigate the effect of SFN on macrophage polarization ...  Read More

Original Article
Intervention with ICOSL Antibodies Alleviates Inflammatory Infiltrations in Mice with Neutrophilic Asthma

Heting Dong; Yinying Ren; Yiyi Song; Wei Ji; Yongdong Yan; Canhong Zhu; Li Huang; Meijuan Wang; Wenjing Gu; Xinxing Zhang; Huiming Sun; Chuangli Hao; Zhengrong Chen

Volume 21, Issue 1 , March 2024, Pages 53-64


  Background: Neutrophilic asthma is characterized by the predominant infiltration of neutrophils in airway inflammation.Objective: To explore the therapeutic potential of an antibody against the inducible T cell co-stimulator ligand (ICOSL) in a mouse model of neutrophilic asthma.Methods: Female BALB/c ...  Read More

Original Article
Serum Interleukin-38 and Tumor-Infiltrating Lymphocytes in Primary Brain Tumors

Mohammad Reza Haghshenas; Aida Khademolhosseini; Amirreza Dehghanian; Fereshteh Ghanipour; Hamid Ghaderi; Soolmaz Khansalar; Abdolreza Sotoodeh Jahromi

Volume 21, Issue 1 , March 2024, Pages 65-73


  Background: Tumor-infiltrating lymphocytes (TILs) and brain stromal cells produce immunosuppressive cytokines, contributing to an immunosuppressive tumor microenvironment (TME). Interleukin-38 (IL-38) is a novel anti-inflammatory cytokine and a natural modulator of the innate and adaptive immune system. ...  Read More

Original Article
IL-27 Levels in Bronchoalveolar Lavage Fluid in Children with Post-infectious Bronchiolitis Obliterans

Wenjing Liu; Yiyao Zhang; Xia Chen

Volume 21, Issue 1 , March 2024, Pages 74-80


  Background: Pulmonary neutrophils may play a crucial role in the development of bronchiolitis obliterans (BO) following measles virus infection. IL-27 could potentially have a negative regulatory effect on the release of reactive oxygen species and cytotoxic granules in neutrophils.Objective: To investigate ...  Read More

Original Article
Abnormal Changes in IL-13 and IL-17A Serum Levels in Children with Adenovirus Pneumonia and their Diagnostic Value

Jianbo Jiang; Lili Sun; Meixia Huang

Volume 21, Issue 1 , March 2024, Pages 81-88


  Background: Human adenovirus (HAdV) is an enveloped icosahedral DNA virus. HAdV infection can lead to immune system damage, resulting in decreased numbers and compromised function of T cells and B cells. It can also cause an imbalanced Th1/Th2 ratio and dysregulation of pro-inflammatory and anti-inflammatory ...  Read More

Original Article
MicroRNA-150 Deletion Reduces the Occurrence and Severity of Rheumatoid Arthritis by Inhibiting IL-17

Aihong Zhang; Quanhui Zheng

Volume 21, Issue 1 , March 2024, Pages 89-100


  Background: Understanding the effects of epigenetic factors on the pathogenesis of rheumatoid arthritis (RA) is important for the early diagnosis and therapeutic intervention of this disease. MicroRNA-150 (miR-150) exerts an important influence on the development and function of lymphocytes. However, ...  Read More

Letter To The Editor
Letter to the Editor Regarding “Antibody Production after COVID-19 Vaccination in Patients with Inborn Errors of Immunity”

Nitin Deshpande

Volume 21, Issue 1 , March 2024, Pages 101-102


  Dear Editor I am writing in response to the recently published study titled "Antibody Production after COVID-19 Vaccination in Patients with Inborn Errors of Immunity" (1). The article offers essential insights into the immune response engendered by COVID-19 vaccines in a vulnerable cohort. To build ...  Read More