Volume 21 (2024)
Volume 20 (2023)
Volume 18 (2021)
Volume 17 (2020)
Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)
Original Article
Frequency of CD39+, LAG3+, and CTLA4+ Regulatory T Cells in Two Different Immunosuppressive Protocols in Renal Allograft Recipients (Sirolimus vs Mycophenolate mofetil): A Cohort Report

Yaghoub Mollaei-Kandelous; Pedram Ahmadpoor; Mohsen Nafar; Mohammad Reza Khatami; Samad Farashi Bonab; Nader Tajik; Mahdi Shekarabi; Aliakbar Amirzargar

Volume 19, Issue 3 , September 2022, Pages 219-231


  Background: Impaired renal function is considered as a significant risk factor for cardiovascular events in chronic kidney disease patients. Several immunosuppressive drugs are used in these patients, which necessitates to minimize the drug-related side effects by employing alternative strategies.Objective: ...  Read More

Original Article
The Proportion of Vδ1T Cells in Peripheral Blood Correlated with Prognosis of Sepsis

Fawei Yuan; Huan Yin; Juan Tan; Kun Zheng; Xiping Mei; Lixue Yuan

Volume 19, Issue 3 , September 2022, Pages 232-242


  Background: Sepsis is a serious condition with a high mortality rate, and septic patients often have organ dysfunction, low tissue perfusion and hypoxia, lactic acidosis, oliguria, or functional brain changes.Objective: To observe the number and the function of Vδ1T cells in peripheral blood of ...  Read More

Original Article
Mycobacterium Vaccae Regulate γδT17 and γδTreg Cells in Mice Asthmatic Lung

Yien Yao; Xiaoju Chen; Caicheng Qin; Jianlin Huang; Siyue Xu; Chaoqian Li

Volume 19, Issue 3 , September 2022, Pages 243-254


  Background Dysregulation of the balance between different T cell populations is believed to be an important basis for asthma.Objective To observe the changes in γδT subtypes in transgenic asthmatic mice after aerosol inhalation of Mycobacterium vaccae, and to further investigate the mechanism ...  Read More

Original Article
Rosuvastatin Intervention Decreased the Frequencies of the TIM-3+ Population of NK Cells and NKT Cells among Patients with Chronic Hepatitis B

Alireza Norouzi; Shohreh Taziki; Ali Najafipasandi; Saeed Mohammadi; Gholamreza Roshandel

Volume 19, Issue 3 , September 2022, Pages 255-262


  Background: Natural killer (NK) cells are dichotomously involved in chronic hepatitis B (CHB) infection as principal members of innate immunity. An effective treatment should enhance the antiviral potentials of NK cells and not their immunomodulatory roles. TIM-3 (T-cell immunoglobulin and mucin-containing ...  Read More

Original Article
Impairment of a NIK-SIX Feedback Axis Results in Dysregulation of Intestinal Immune Homeostasis and Promotes Early-onset Fatal Spontaneous Colitis

Yu Xia Zhao; Hong Mei; Yang Xin Huang; Jia Qing Chen

Volume 19, Issue 3 , September 2022, Pages 263-277


  Background: The negative feedback circuit NIK-SIN could inhibit the systemic inflammation and protect mouse from endotoxic shock. However, the physiological significance of NIK-SIX feedback circuit in the maintenance of intestinal immune homeostasis and prevention of early-onset spontaneous colitis is ...  Read More

Original Article
Optimization of an Efficient Cell Culture Hepatitis B Infection System for Assessment of Hepatitis B Virus Neutralizing Monoclonal Antibodies

Hamzeh Sarvnaz; Sahar Asadi-Asadabad; Mohammad Mehdi Amiri; Mojgan Ghaedi; Ulrike Protzer; Mahmood Jeddi-Tehrani; Forough Golsaz-Shirazi; Fazel Shokri

Volume 19, Issue 3 , September 2022, Pages 278-298


  Background: Human polyclonal plasma-derived hepatitis B immunoglobulin (HBIG) is currently used for immunoprophylaxis of HBV infection. The development of virus-neutralizing monoclonal antibodies (MAbs) requires the use of optimized cell culture systems supporting HBV infection.Objective: This study ...  Read More

Original Article
Effects of Lipopolysaccharide from Porphyromonas gingivalis and Escherichia coli on Gene Expression Levels of Toll-like Receptors and Inflammatory Cytokines in Human Dental Pulp Stem Cells

Hanieh Mojtahedi; Nikoo Hossein-khannazer; Seyed Mahmoud Hashemi; Mina Masoudnia; Monireh Askarzadeh; Arash Khojasteh; Mandana Sattari

Volume 19, Issue 3 , September 2022, Pages 299-310


  Background: Periodontal diseases originate from a group of oral inflammatory infections initiated by oral pathogens. Among these pathogens, Gram-negative bacteria such as p. gingivalis play a major role in chronic periodontitis. P. gingivalis harbours lipopolysaccharide (LPS) which enables it to attach ...  Read More

Original Article
The Chemokine MIG is Associated with an Increased Risk of COVID-19 Mortality in Mexican Patients

Luis Antonio Ochoa-Ramirez; Rosalio Ramos-Payan; German Reynaldo Jimenez-Gastelum; Jose Rodriguez-Millan; Maribel Aguilar-Medina; Juan Jose Rios-Tostado; Alfredo Ayala-Ham; Mercedez Bermudez; Juan Fidel Osuna-Ramos; Vicente Olimon-Andalon; Jesús Salvador Velarde-Félix

Volume 19, Issue 3 , September 2022, Pages 311-320


  Background: Coronavirus disease 2019 (COVID-19) is an emergent viral disease in which the host inflammatory response modulates the clinical outcome. Severe outcomes are associated with an exacerbation of inflammation in which chemokines play an important role as the attractants of immune cells to the ...  Read More

Original Article
Comparison of the Antibody Responses Following Vaccination with AstraZeneca and Sinopharm

Enayat Anvari; Atefe Ghamar Talepoor; Mahsa Eshkevar Vakili; Narges Karimi; MohammadReza Ataollahi; Gelareh Najafi; Dieter Kabelitz; Iraj Ahmadi; Kurosh Kalantar

Volume 19, Issue 3 , September 2022, Pages 321-329


  Background: Vaccines are the most effective way to prevent Coronavirus 2 severe acute respiratory syndrome (SARS-CoV-2).Objectives: To compare the antibody response of healthy individuals vaccinated with either the AstraZeneca (ChAdOx1 nCoV-19) or the Sinopharm (BBIBP-CorV) vaccine, in those ...  Read More

Review Article
Labor Could Increase Systemic Inflammation and Cause or Deteriorate Cytokine Storm in COVID-19

Amir Hossein Norooznezhad; Alireza A Shamshirsaz; Sedigheh Hantoushzadeh

Volume 19, Issue 3 , September 2022, Pages 330-336


  Pregnant women with coronavirus disease 2019 (COVID-19) have a higher risk of morbidity and mortality compared with the general population. Possible pathways are: I) in patients with COVID-19, cytokine storm defined as the excess release of pro-inflammatory cytokines such as interleukin 1β (IL-1β), ...  Read More

Letter To The Editor
Letter to the Editor Regarding "An Overview on Serology and Molecular Tests for COVID-19: An Important Challenge of the Current Century (doi: 10.22034/iji.2021.88660.1894.)"

Milad Zandi; Emad Behboudi; Mohammad Reza Shojaei; Saber Soltani; Hassan Karami

Volume 19, Issue 3 , September 2022, Pages 337-337


  Recently in a review article by Mansourabadi et al. published in the Iranian Journal of Immunology, the authors described the serological and molecular tests for COVID-19 (1). The mentioned review considered helicase (Hel) as a structural protein of SARS-CoV-2 (1). However, based on evidence, the genome ...  Read More