Volume 21 (2024)
Volume 20 (2023)
Volume 19 (2022)
Volume 18 (2021)
Volume 17 (2020)
Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)
Functional Property and Regulatory Mechanism of Macrophages in Complementary and Alternative Medicine: From Bench to Clinic

Can Hu; Yizhi Zhang; Junjiang Liu; Yanyan You; Fanglong Wu; Hongmei Zhou

Volume 21, Issue 2 , June 2024, , Pages 103-120


  Complementary and alternative medicine (CAM) includes a wide range of treatments that are gaining acceptance among the public. It is increasingly being recognized as a viable option for treating various diseases with minimal side effects. Common avenues of this therapy include herbal medicine, acupuncture, ...  Read More

Evaluation of Monocyte Subpopulations in Patients with Systemic Sclerosis and its Association with Clinical Manifestations of the Disease: a Cross-sectional Controlled Study

Elham Safarzadeh; Vahid Asghariazar; Shohreh Pordel; Elham Baghbani; Asgar Fekri; Afsaneh Enteshari-Moghaddam

Volume 21, Issue 2 , June 2024, , Pages 147-157


  Background: Systemic sclerosis (SSc) is a chronic autoimmune disorder characterized not only by fibrosis and vasculopathy but also by inflammation. Previous studies have demonstrated monocyte involvement in SSc development, suggesting a role for immune dysfunction in SSc pathogenesis.Objective: To investigate ...  Read More

Angiopoietin-like 4 (ANGPTL4) Suppression Ameliorates Lupus Nephritis in MRL/lpr Mice by Inactivating NLRP3 Inflammasome and Inhibiting Inflammatory Response

Dan Luo; Jun Li; Manli Hu; You Wang; Pei Pi; Min Ning; Jun Wu

Volume 20, Issue 3 , September 2023, , Pages 316-326


  Background: Lupus nephritis (LN) refers to the injury caused by systemic lupus erythematosus (SLE) involving the kidneys. A previous study identified angiopoietin-like protein 4 (ANGPTL4) as a novel urinary biomarker for tracking disease activity in LN.Objective: To investigate the detailed role and ...  Read More

Increased Serum Levels of IL-1β after Ischemic Stroke are Inversely Associated with Vitamin D

Mahnaz Bayat; Niloufar Razavi Moosavi; Najmeh Karimi; Moosa Rahimi; Afshin Borhani-Haghighi

Volume 20, Issue 3 , September 2023, , Pages 359-367


  Background: The initial inflammatory reaction starts following occlusion in ischemic stroke (IS). Interleukin-1β (IL-1β) is a pro-inflammatory cytokine with a crucial role in the pathogenesis of neurodegenerative disorders.Objective: To investigate the levels of IL-1β and vitamin D (VitD) ...  Read More

Elevated HSP70 and HSP90 as Predictive Markers of Immune Activation and Lung Injury in SARS-COV-2 Disease

Zivar Zangeneh; Gholamreza Khamisipour

Volume 20, Issue 3 , September 2023, , Pages 368-373


  Background: Heat shock proteins (HSPs) are involved in innate and adaptive immune responses, especially inflammatory responses due to immune cell activation. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was one of the most important causes of death in the recent pandemic. Increased cellular ...  Read More

Teucrium polium Extract Attenuates Inflammation in Asthma by Reducing RORγt Transcription and Increasing IL-10 Secretion in an Ovalbumin-induced Murine Asthma Model

Shole Daneshvar-ghahfarokhi; Amir Rahnama; Vahid Mohammadi-Shahrokhi

Volume 20, Issue 2 , June 2023, , Pages 159-166


  Background: One of the inflammatory diseases of the respiratory system is asthma. Teucrium polium (TP) has anti-inflammatory and anti-allergic properties and its anti-asthmatic effects have not been investigated yet. RORγt is an inflammatory transcription factor for Th17 differentiation. By secreting ...  Read More

Activation of β2-adrenergic Receptor Alleviates Collagen-induced Arthritis by Ameliorating Th17/Treg Imbalance

Jian-Hua Lu; Xiao-Xiao Rui; Ting-Ting Wang; Xiao-Qin Wang; Yu-Ping Peng; Yi-Hua Qiu

Volume 20, Issue 1 , March 2023, , Pages 16-25


  Background: Recent research in our laboratory shows that CD4+ T cells express the β2 adrenergic receptor (β2-AR), and the sympathetic neurotransmitter norepinephrine regulates the function of T cells via β2-AR signaling. However, the immunoregulatory effect of β2-AR and its related ...  Read More

Enzyme-Assisted Extraction of Narirutin from Citri Reticulatae Pericarpium and Anti-allergic Asthma Activity

Xiaolei Shi; Lina Zhao; Liyan Niu; Jhao Wei; Xuwen Li; Yongri Jin

Volume 19, Issue 4 , December 2022, , Pages 385-394


  Background: Asthma is a heterogeneous disorder of the airways related to inflammation; it affects millions of people worldwide. Due to the side effects of inhaled corticosteroids, researchers focused on the therapeutic effects of compounds derived from natural products. Objective: To investigate the ...  Read More

Labor Could Increase Systemic Inflammation and Cause or Deteriorate Cytokine Storm in COVID-19

Amir Hossein Norooznezhad; Alireza A Shamshirsaz; Sedigheh Hantoushzadeh

Volume 19, Issue 3 , September 2022, , Pages 330-336


  Pregnant women with coronavirus disease 2019 (COVID-19) have a higher risk of morbidity and mortality compared with the general population. Possible pathways are: I) in patients with COVID-19, cytokine storm defined as the excess release of pro-inflammatory cytokines such as interleukin 1β (IL-1β), ...  Read More

Upregulation of Interleukin-6 in HPV-Positive Breast Cancer Patients

Javad Charostad; Azarakhsh Azaran; Mohsen Nakhaei; Akram Astani; Gholam Abbas Kaydani; Azim Motamedfar; manoochehr makvandi

Volume 18, Issue 4 , December 2021, , Pages 315-330


  Background: Interleukin-6 (IL-6) is a well-known proinflammatory cytokine with tumor promoting capacity in various forms of malignancies including breast cancer (BC). Data highlighted the substantial role of HPV in the pathogenesis of BC. Compelling evidence suggests the contribution of HPV in carcinogenesis ...  Read More

Propylene-Glycol Aggravates LPS-Induced Sepsis through Production of TNF-α and IL-6

Annamaria Marton; Csongor Kolozsi; Erzsebet Kusz; Zoltan Olah; Tamas Letoha; Csaba Vizler; Laszlo Pecze

Volume 11, Issue 2 , June 2014, , Pages 113-122

  Background : Propylene glycol (1,2-propanediol, PG) is a commonly used solvent for oral, intravenous, as well as topical pharmaceutical preparations. While PG is generally considered to be safe, it has been known that large intravenous doses given over a short period of time can be toxic. Objective: ...  Read More

Negative Association of Serum IL-6 and IL-17 with Type-II Diabetes Retinopathy

Nadeem Afzal; Shakeela Zaman; Aneela Asghar; Khursheed Javed; Faheem Shahzad; Abu Zafar; Abdul Hanan Nagi

Volume 11, Issue 1 , March 2014, , Pages 40-48

  Background: Diabetes mellitus (DM) is a health concern which leads to complications such as retinopathy. Pakistan has 6.9 million people living with DM and this toll will be doubled by 2025. Objective: To determine serum IL-6 and IL-17 of type 2 diabetes mellitus (T2DM) patients with retinopathy. Methods: ...  Read More

Monocyte Expression of Toll-like Receptor-4 in Patients with Stable Angina Undergoing Percutanoeus Coronary Intervention

Bahador Bagheri; Bahram Sohrabi; Aliakbar Movassaghpur; Siminozar Mashayekhi; Afagh Garjani; Mehriar Shokri; Mohammad Noori; Alireza Garjani

Volume 9, Issue 3 , September 2012, , Pages 149-158

  Background: Toll like receptors (TLRs) are well recognized players in inflammatory conditions. Among them TLR-4 is involved in chronic inflammatory processes such as formation of atherosclerotic plaques. Objective: The present study was aimed to examine the effects of percutanoeus coronary intervention ...  Read More

Toll Like Receptor-4 896A/G Gene Variation, a Risk Factor for Migraine Headaches

Alireza Rafiei; Mahoud Abedini; Seyed Hamzeh Hosseini; Zahra HosseiniKhah; Behrouz Bazrafshan; Mohsen Tehrani

Volume 9, Issue 3 , September 2012, , Pages 159-167

  Background: The pathogenesis of migraine involves immune-mediated mechanisms in the vascular endothelium. Toll like receptor 4 (TLR-4) is a signaling receptor of innate immunity which plays a role in various neuropathologies related to neuron inflammation. Objective: This case/control study is aimed ...  Read More

Serum Interleukin-23 Levels in Patients with Ulcerative Colitis

Mojgan Mohammadi; Mohammad Mahdi Hayatbakhsh; Mohammad Javad Zahedi; Mohammad Reza Jalalpour; Amin Pakgohar

Volume 8, Issue 3 , September 2011, , Pages 183-188

  Background: Patients with ulcerative colitis are at increased risk of inflammation. Interleukin 23 (IL-23) is a newly identified cytokine with increased expression in inflamed biopsies of colon mucosa in patients with Crohn's disease; however, there is inconsistent evidence on its role in ulcerative ...  Read More

Level of Nitric Oxide in Bronchoalveolar Lavage Fluid of Asthmatic Mice Model

Alireza Salek Moghaddam; Mohammad Shabani; Farahdokht Fateminasab; Mohammad Reza Khakzad

Volume 2, Issue 2 , June 2005, , Pages 103-110

  Background: Asthma is a chronic inflammatory disease with multifactorial and complicated mechanisms. Elevated level of exhaled Nitric Oxide (NO) in asthma and other inflammatory lung diseases has led to many studies examining NO as a potential marker of airway inflammation. Objective: This study was ...  Read More