Volume 17 (2020)
Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)
1. CEA Plasmid as Therapeutic DNA Vaccination against Colorectal Cancer

Ziba Veisi Malekshahi; Nasser Hashemi Goradel; Mehdi Shakouri Khomartash; Amir Maleksabet; Maryam kadkhodazadeh; Gholam Ali Kardar; Babak Negahdari

Volume 16, Issue 3 , Summer 2019, , Pages 235-245


  Background: Human colorectal cancer cells overexpress carcinoembryonic antigen (CEA). CEA is a glycoprotein which has shown to be a promising vaccine target for immunotherapy against colorectal cancer. Objective: To design a DNA vaccine harboring CEA antigen and evaluate its effect on inducing immunity ...  Read More

2. Immunogenicity of a DNA Vaccine Encoding Ag85a-Tb10.4 Antigens from Mycobacterium Tuberculosis

Zahra Meshkat; Amir Teimourpour; Samira Rashidian; Mohsen Arzanlou; Roghayeh Teimourpour

Volume 13, Issue 4 , Autumn 2016, , Pages 289-295

  Background: Tuberculosis is a life threatening disease that is partially prevented by BCG vaccine. Development of more effective vaccines is an urgent priority in TB control. Ag85a and Tb10.4 are the members of culture filter protein (CFP) of M. tuberculosis that have high immunogenicity. Objective: ...  Read More

3. Quantiation of IL-4, IL-10 and IFN- Genes Expression after Immunization of Mice with CFP-10 and ESAT-6 Containing Vectors

Azam Torabi; Mojtaba Tahmoorespur; Fatemeh Vahedi; Nader Mosavari; Mohammadreza Nassiri

Volume 10, Issue 4 , Autumn 2013, , Pages 205-215

  Background: Tuberculosis is a disease with high morbidity, caused mainly by Mycobaterium tuberculosis (M.tb.). DNA vaccines show a promising future due to their unique advantages over conventional methods. The early-secreted antigen target (ESAT)-6 and culture filtrate protein (CFP)-10 of M.tb. antigens ...  Read More

4. An Endogenous Immune Adjuvant Released by Necrotic Cells for Enhancement of DNA Vaccine Potency

Rohollah Dorostkar; Taravat Bamdad; Masoud Parsania; Hassan Pouriayevali

Volume 9, Issue 4 , Autumn 2012, , Pages 215-225

  Background: Improving vaccine potency in the induction of a strong cell-mediated cytotoxicity can enhance the efficacy of vaccines. Necrotic cells and the supernatant of necrotic tumor cells are attractive adjuvants, on account of their ability to recruit antigen-presenting cells to the site of antigen ...  Read More

5. Immune Responses against a New HIV-1 p24-gp41/pCAGGS-IL-12 DNA Vaccine in Balb/c Mice

Fatemeh Roodbari; Farzaneh Sabahi; Mohamad Nabi Sarbolouki; Farzaneh Barkhordari; Ahmad Adeli; Amel Jamedar; Fereidoun Mahboudi

Volume 9, Issue 2 , Spring 2012, , Pages 86-97

  Background: Development of an effective vaccine is highly needed in order to restrict the AIDS pandemic. DNA vaccines initiate both arms of immunity without the potential of causing disease. HIV-1 p24 and gp41 (gag and env) proteins play important roles in viral pathogenesis and are effective candidates ...  Read More

6. Strong Immune Responses Induced by a DNA Vaccine Containing HPV16 Truncated E7 C-terminal Linked to HSP70 Gene

Zahra Meshkat; Hoorieh Soleimanjahi; Hessam Mirshahabi; Mojtaba Meshkat; Maryam Kheiandish; Zuhair Mohammad Hassan

Volume 8, Issue 2 , Spring 2011, , Pages 65-75

  Background: Vaccines capable of controlling tumor virus based infections are found difficult to develop due to the consistence latent infection in the host. DNA vaccines are attractive tools for the development of HPV vaccines and inducing antigen-specific immunity owing to the stability, simplicity ...  Read More

7. The Effect of Cationic Liposomes Encapsulating pcDNA3.1+PA Plasmids on Humoral Immune Response in Mice

Fatemeh Vahedi; Mahmoud Reza Jaafari; Mahmoud Mahmoudi

Volume 7, Issue 4 , Autumn 2010, , Pages 210-216

  Background: DNA vaccines are third generation vaccines which have made promises to combat infectious diseases. Cationic liposomes are used as effective delivery systems for DNA vaccines to generate stronger immunity. Objective: Encapsulation of pcDNA3.1+PA plasmid, encoding protective antigen (PA) of ...  Read More

8. CTL Responses to a DNA Vaccine Encod-ing E7 Gene of Human Papillomavirus Type 16 from an Iranian Isolate

Zahra Meshkat; Hoorieh Soleimajjahi; Mahmoud Mahmoudi; Zuhair Mohammad Hassan; Hessam Mirshahabi; Mojtaba Meshkat; Maryam Kheirandish

Volume 5, Issue 2 , Spring 2008, , Pages 82-91

  Background: Cervical cancer is the most prevalent tumor in developing countries and the second most frequent cancer among female population worldwide. Specific human papillomaviruses and, most notably, HPV types 16 and 18 are recognized as being caus-ally associated with cervical carcinomas. The early ...  Read More

9. Construction of a Eukaryotic Plasmid Encoding Bacillus anthracis Protective Antigen, a Candidate for DNA Vaccine

Fatemeh Vahedi; Naser Taiebi Meibody; Mahdi KianiZadeh; Mahmoud Mahmoudi

Volume 2, Issue 3 , Summer 2005, , Pages 134-140

  Background: DNA immunization with plasmid DNA encoding bacterial, viral, parasitic and tumor antigens has been reported to trigger protective immunity. Objective: To evaluate the use of a DNA immunization strategy for protection against anthrax, a plasmid was constructed. Methods: The partialsequence ...  Read More