Iranian Journal of Immunology

IL-25 and IL-33 Serum Levels are not Associated with the Type of Allergen Causing Allergic Rhinitis

Document Type : Short Paper

Authors

Reza Abbasi 1, 2
Kamiar Zomorodian 3
Zahra Zare Shahrabadi 4
Farshid Saadat 5
Seyed Hesamedin Nabavizadeh 1
Hossein Esmaeilzadeh 1
Sohila Alyasin 1

1 Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

2 Department of Pediatrics Allergy and Immunology, Yasuj University of Medical Sciences, Yasuj, Iran

3 Basic Sciences in Infectious Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

4 Department of Parasitology and Mycology, School of Public Health, Shiraz University of Medical Sciences, Shiraz, Iran

5 Department of Immunology, School of Public Health, Guilan University of Medical Sciences, Guilan, Iran

https://doi.org/10.22034/iji.2019.80283
Abstract
Background: Fungal aeroallergens might sensitize the airway which in turn produces a specific cytokine profile. Objective: To evaluate the IL-25 and IL-33 profile in patients with fungal allergic rhinitis. Methods: The present study examined patients who were evaluated due to allergic rhinitis (AR) at Emam Reza Hospital of Shiraz, Iran. The allergic patients were categorized based on the skin prick test. Blood samples were collected and allergen-specific IgE and cytokine profiles were analyzed. Results: 184 patients were enrolled in the study and in 35 of whom fungal rhinitis was confirmed. The levels of specific IgE in patients with fungal allergy were statistically significant compared to those in the control group (p<0.000). However, there were no significant differences in IL-25 and IL-33 levels between fungal and none-fungal AR patients. Conclusion: Chronic fungal challenge might regulate innate system cytokines in severe persistent AR.

Keywords

Allergic Fungal Sinusitis
Interleukin-25
Interleukin-33
IgE
Iranian Journal of Immunology
Volume 16, Issue 4
Autumn 2019
Pages 321-326

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