Iranian Journal of Immunology

Circulating Levels of Pro-inflammatory Cytokines in Patients with Nonalcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis

Document Type : Short Paper

Authors

Abolghasem Hadinia 1
Amir Hossein Doustimotlagh 2, 3
Hamed Reza Goodarzi 1
Arash Arya 4
Mojtaba Jafarinia 1

1 Department of Genetic, Marvdasht branch, Islamic Azad University, Marvdasht, Iran

2 Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran

3 Department of Clinical Biochemistry, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran

4 Internal Medicine, Yasuj University of Medical Sciences, Yasuj, Iran

https://doi.org/10.22034/iji.2019.80284
Abstract
Background: Pro-inflammatory cytokines are associated with systemic inflammatory responses. Objective: To investigate the levels of pro-inflammatory cytokines (IL-1b, IL-6, and TNF-a) in patients with non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH) compared to healthy individuals. Methods: This case-control study was conducted on 30 patients with NAFL, 30 patients with NASH, and 30 healthy volunteers. The plasma level of IL-1b, IL-6, and TNF-a were determined by ELISA, and biochemical parameters were measured using colorimetric methods. Results: IL-1b and IL-6 levels were significantly higher in patients with NASH compared with NAFL and control group. However, TNF-a levels had no significant variations in NAFL and NASH patients compared to the control group (p=0.903 and p=0.960, respectively). Conclusion: Results showed that the levels of ALT activity and pro-inflammatory cytokines were higher in patients with NASH compared to control and NAFL subjects; Therefore, steatosis and inflammation develop as a result of excessive pro-inflammatory factors in NASH.

Keywords

Interleukin-1β
Interleukin-6
Non-Alcoholic Fatty Liver
Non-Alcoholic Steatohepatitis
Tumor Necrosis Factor-α
Iranian Journal of Immunology
Volume 16, Issue 4
Autumn 2019
Pages 327-333

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