Volume 17 (2020)
Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)
1. Correlation of 4-1BBL+ B Cells in Tumor Draining Lymph Nodes with Pathological Characteristics of Breast Cancer

Mohsen Arabpour; Atri Ghods; Mahmoud Shariat; Abodl-Rasoul Talei; Fereshteh Mehdipour; Abbas Ghaderi

Volume 16, Issue 2 , Spring 2019, , Pages 108-116


  Background: B cells can increase the expression of granzyme B in CD8+ T cells through 4-1BBL/4-1BB interaction and promote anti-tumor immunity. Objective: To investigate the expression of 4-1BBL on B cells in the breast tumor draining lymph nodes (TDLNs) and its association with disease parameters. Methods: ...  Read More

2. Induction of T Regulatory Subsets from Naïve CD4+ T Cells after Exposure to Breast Cancer Adipose Derived Stem Cells

Mahboobeh Razmkhah; Nadieh Abedi; Ahmad Hosseini; Mohammad Taghi Imani; Abdol-Rasoul Talei; Abbas Ghaderi

Volume 12, Issue 1 , Winter 2015, , Pages 1-15

  Background: Adipose derived stem cells (ASCs) provoke the accumulation and expansion of regulatory T cells, leading to the modulation of immune responses in tumor microenvironment. Objective: To assess the effect of tumoral ASCs on the trend of regulatory T cells differentiation. Methods: Peripheral ...  Read More

3. IL-17 and IL-4 Producing CD8+ T Cells in Tumor Draining Lymph Nodes of Breast Cancer Patients: Positive Association with Tumor Progression

Zahra Faghih; Somayeh Rezaeifard; Akbar Safaei; Abbas Ghaderi; Nasrollah Erfani

Volume 10, Issue 4 , Autumn 2013, , Pages 193-204

  Background: CD8+ cytotoxic T lymphocytes have been recently divided based on their cytokine expression profile. Objective: To evaluate the percentages of CD8+ lymphocytes and their effector subsets including Tc1, Tc2 and Tc17 in the tumor draining lymph nodes (TDLNs) of patients with breast cancer. Methods: ...  Read More

4. CCL22 16C/A Genetic Variation is not Associated with Breast Carcinoma in Southern Iranian Population

Nasrollah Erfani; Faezeh Moghaddasi-Sani; Mahboubeh Razmkhah; Mohammad Reza Haghshenas; Abdolrasoul Talaei; Abbas Ghaderi

Volume 9, Issue 4 , Autumn 2012, , Pages 226-233

  Background: CCL22/MDC is a CC chemokine with a critical role in regulation of the immune balance in physiological condition. CCL22/CCR-4 ligation has been documented to participate in the migration of regulatory T (Treg) cells and Th2 lymphocytes to the site of breast tumors; circumstances that are known ...  Read More

5. Strong Association of CTLA-4 Variation (CT60A/G) and CTLA-4 Haplotypes with Predisposition of Iranians to Head and Neck Cancer

Nasrollah Erfani; Mohammad Reza Haghshenas; Mohammad Ali Hoseini; Seyed Basi Hashemi; Bijan Khademi; Abbas Ghaderi

Volume 9, Issue 3 , Summer 2012, , Pages 188-198

  Background: Variations in Cytotoxic T Lymphocyte Antigen-4 (CTLA-4) affect the expression and function of this protein. Objective: We aimed to investigate the association of +49 A/G (rs231775), +1822 C/T (rs231779) and +6230 A/G (CT60, rs3087243) genetic variations, as well as the merged haplotypes in ...  Read More

6. CTLA4 Gene Variants in Autoimmunity and Cancer: a Comparative Review

Abbas Ghaderi

Volume 8, Issue 3 , Summer 2011, , Pages 127-149

  Gene association studies are less appealing in cancer compared to autoimmune diseases. Complexity, heterogeneity, variation in histological types, age at onset, short survival, and acute versus chronic conditions are cancer related factors which are different from an organ specific autoimmune disease, ...  Read More

7. Mesenchymal Stem Cells Do Not Suppress Lymphoblastic Leukemic Cell Line Proliferation

Neda Mousavi Niri; Mansooreh Jaberipour; Mahboobeh Razmkhah; Abbas Ghaderi; Mojtaba Habibagahi

Volume 6, Issue 4 , Autumn 2009, , Pages 186-194

  Background: Several studies have demonstrated the immunosuppresive effects of mes-enchymal stem cells (MSCs) in allogeneic or mitogenic interactions. Cell-cell contact inhibition and secretion of suppressive soluble factors have been suggested in this re-gard. Objective: To investigate if adipose derived ...  Read More

8. Analysis of Human Leukocyte Antigen class II Gene Polymorphism in Iranian Patients with Papillon-Lefevre Syndrome: a Family Study

Shirin Farjadian; Mehrdad Lotfazar; Abbas Ghaderi

Volume 5, Issue 3 , Summer 2008, , Pages 171-176

  Background: Papillon-Lefevre syndrome (PLS) is a rare autosomal recessive disorder characterized by palmoplantar hyperkeratosis and early development of aggressive pe-riodontitis. Although cathepsin C (CTSC) gene mutations have been established in about 70-80% of PLS patients, it is assumed that the ...  Read More

9. Production and Characterization of a Monoclonal Antibody against an Antigen on the Surface of Non-Small Cell Carcinoma of the Lung

Sedigheh Sharifzadeh; Helmout Modjtahedi; Mahmood Jedi Tehrani; Abbas Ghaderi

Volume 4, Issue 4 , Autumn 2007, , Pages 206-214

  Background: Lung carcinoma is a multiple type cancer comprising of small cell and non-small cell carcinomas (NSCLC). For therapeutic and diagnostic purposes, serum monoclonal antibodies have been produced against lung cancer. Objective: To charac-terize a murine monoclonal antibody (ME3D11) reactive ...  Read More

10. HLA class II Genetic Diversity in Arabs and Jews of Iran

Shirin Farjadian; Abbas Ghaderi

Volume 4, Issue 2 , Spring 2007, , Pages 85-93

  Background: Anthropological studies based on highly polymorphic HLA genes pro-vide useful information for bone marrow donor registry, forensic medicine, disease as-sociation studies, as well as designing peptide vaccines against tumors, and infectious or autoimmune diseases. Objective: This study was ...  Read More

11. IgM, IgG, IgA Serum Levels and Lymphocytes Count Before and After Adenotonsillectomy

Abolhassan Faramarzi; Azra Shamsdin; Abbas Ghaderi

Volume 3, Issue 4 , Autumn 2006, , Pages 187-191

  Background: Tonsils and adenoids are involved in both local immunity and immune surveillance for the development of immune defense mechanisms. A number of investigators have found decreased immunoglobulin levels after adenotonsillectomy while others have failed to find significant changes. The effects ...  Read More

12. Iranian Lurs Genetic Diversity: An Anthropological View Based on HLA Class II Profiles

Shirin Farjadian; Abbas Ghaderi

Volume 3, Issue 3 , Summer 2006, , Pages 106-113

  Background: HLA genes are highly polymorphic and certain alleles are frequent only in specific populations. Therefore, HLA is a unique tool for studying the genetic relationship between different populations. Iranians are ethnically diverse people and one of the major ethnic groups in Iran is Lur population ...  Read More

13. Determination of Soluble HER-2/neu (sHER-2/neu) in Iranian Patients with Lung Cancer

Seyyed Mohammad Ali Ghayumi; Kambiz Aghasadeghi; Mehrnoosh Dorouchi; Abbas Ghaderi

Volume 3, Issue 2 , Spring 2006, , Pages 61-65

  Background: The HER-2/neu gene is located on chromosome 17q21 and encodes a 185-kDa transmembrane glycoprotein with tyrosine kinase activity reported to be released in soluble form in various malignancies. Objective: To evaluate the clinical significance of soluble Her-2/neu as a diagnostic marker in ...  Read More

14. Serum Level of HER-2 Extracellular Domain in Iranian Patients with Breast Cancer: A Follow-up Study

Mehrnoosh Doroudchi; Abdolrasoul Talei; Helmout Modjtahedi; Alamtaj Samsami Dehaghani; Abdol Mohammad Pezeshki; Hilary Thomas; Abbas Ghaderi

Volume 2, Issue 4 , Autumn 2005, , Pages 191-200

  Background: A soluble form of HER-2/neu extracellular domain (sHER-2) is reported to be released in the sera of metastatic breast cancer patients. Objective: To measure the level of sHER-2 in sera of 115 breast cancer patients. Methods: Serial samples of 27 patients with metastasis, 18 non-metastatic ...  Read More

15. Lack of Association between ctla-4 A49G Polymorphism and Vitiligo

Mohammad Javad Fattahi; Abdul Mohammad Pezeshki; Maryam Emad; Mohammad Hosein Lohrasb; Azra Shamseddin; Abbas Ghaderi; Mehrnoosh Doroudchi

Volume 2, Issue 2 , Spring 2005, , Pages 97-102

  Background: Vitiligo is an acquired skin disorder that selectively destroys melanocytes in epidermis with an unknown etiology.   Objective: To investigate the exon 1 A49G polymorphism of cytotoxic T lymphocyte antigen-4 (ctla-4) gene in vitiligo patients.   Methods: The A49G polymorphism was ...  Read More

16. Production and Characterization of Murine Monoclonal Antibodies to Leishmania Gp63 Antigen

Ezzatallah Basiri; Sadreddin Mohseni Ardehali; Mehrnoosh Doroudchi; Fereidoun Mahboodi; Arsalan Kharazmi; Abbas Ghaderi

Volume 1, Issue 3 , Autumn 2004, , Pages 194-199

  Background : Production of monoclonal antibodies to Leishmania antigens assists the identification and characterization of these organisms. Objective: Production of monoclonal antibodies against epitopes on the gp63. Methods: Two murine monoclonal antibodies to gp63 were produced and characterized. The ...  Read More

17. Anticardiolipin Antibodies in Juvenile Rheumatoid Arthritis and Systemic Lupus Erythematosus

Sara Kashef; Reza Amin; Maryam Ayatollahi; Abbas Ghaderi

Volume 1, Issue 2 , Summer 2004, , Pages 117-123

  Background: Antiphospholipid antibody syndrome (APS) can either occur as a primary syndrome or associated with other autoimmune diseases such as systemic lupus erythematosus (SLE). Anticardiolipin antibody (aCL) of IgG and/or IgM isotype in blood, measured by a standardized ELISA is the most acceptable ...  Read More

18. Anticardiolipin Antibody in Patients with Behçet's Disease with and without Vascular Thrombosis

Akbar Rajaee; Mohammad Ali Nazarinia; Seyed Modjtaba Hakim; Mitra Amini; Maryam Ayatollahi; Abbas Ghaderi

Volume 1, Issue 2 , Summer 2004, , Pages 111-117

  Objective: The clinical value of IgG anticardiolipin antibody in patients with Behçet's disease with or without vascular thrombosis was evaluated.   Methods: IgG isotype of anticardiolipin (aCL) antibody was assessed in 40 Behçet's disease (BD) patients with venous or arterial thrombosis, ...  Read More

19. Immunological Correlates of Adult Onset Idiopathic Generalized Tonic-clonic Epilepsy before and after Sodium Valproate Treatment

Gholamali Yousefi-Pour; Sadegh Izadi; Abbas Ghaderi

Volume 1, Issue 2 , Summer 2004, , Pages 105-110

  Objective: To investigate possible immunological humoral correlates in newly diagnosed adult-onset generalized tonic-clonic epilepsy among Iranian patients before and after sodium valproate treatment.   Patients and Methods: 72 adult patients with newly diagnosed idiopathic generalized tonic-clonic ...  Read More

20. Detection of Rheumatoid Factors in Sera and Biopsy Lesions of Vitiligo Patients

Fatemeh Vahedi Darmian; Soheila Joubeh; Mehrnoosh Doroudchi; Behnam Abdollahi; Abbas Ghaderi

Volume 1, Issue 1 , Spring 2004, , Pages 48-55

  Background: Vitiligo is a dermatological disorder of unknown etiology with a common incidence in southern Iran. Presence of autoantibodies to melanocyte antigens suggested an autoimmune basis of the disease. Objective: In this study, the presence of rheumatoid factor (RF) in sera and skin biopsies of ...  Read More

21. Tumor Markers in Patients Undergoing Hemodialysis and Kidney Transplantation

Ali Derakhshan; Masoumeh Mohkam; Abbas Ghaderi; Ghamar Hosseini Alhashemi; Mohammad Hossein Fallahzadeh

Volume 1, Issue 1 , Spring 2004, , Pages 41-47

  Objective: To evaluate the effect of dialysis and kidney transplantation on serum levels of several tumor markers such as PSA, AFP, CA125, CA19- 9, CA15-3, CEA and to compare with normal age matched controls. Methods: Between September of 2000 and July of 2001, the following tumor markers: PSA, AFP, ...  Read More