Volume 18 (2021)
Volume 17 (2020)
Volume 16 (2019)
Volume 15 (2018)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)
Original Article
1. Antitumor Response to a Codon-Optimized HPV-16 E7/HSP70 Fusion Antigen DNA Vaccine

Hoorieh Soleimanjahi; Hadi Razavinikoo; Fatemeh Fotouhi; Abdollah Ardebili

Volume 14, Issue 3 , Summer 2017, Pages 180-191

  Background: Vaccines based on virus-like particles are effective against Human Papilloma Virus (HPV) infection; however, they have not shown a therapeutic effect against HPV-associated diseases. New immunotherapy strategies based on immune responses against tumor antigens can positively affect the clearance ...  Read More

Original Article
2. Rapamycin Inhibits Expansion of Cord Blood Derived NK and T Cell

Monireh Zare; Behnaz Valipour; Seyede Momeneh Mohammadi; Mohammad Nouri; Aliakbar Movassaghpour; Hojjatollah Nozad Charoudeh

Volume 14, Issue 3 , Summer 2017, Pages 192-199

  Background: The mammalian target of rapamycin (mTOR) is important in hematopoiesis. Despite the central role of mTOR in regulating the differentiation of immune cells, the effect of mTOR function on cord blood mononuclear cells is yet to be defined. Objectives: To evaluate the effect of mTOR inhibition, ...  Read More

Original Article
3. Polyclonal Antibody against Different Extracellular Subdomains of HER2 Induces Tumor Growth Inhibition in vitro

Reza Hosseini-Ghatar; Tahereh Soltantoyeh; Motahareh Bahadori; Jalal Khoshnoodi; Forough Golsaz-Shirazi; Mahmood Jeddi-Tehrani; Mohammad Mehdi Amiri; Fazel Shokri

Volume 14, Issue 3 , Summer 2017, Pages 200-214

  Background: Human epidermal growth factor receptor 2 (HER2) has a crucial role in several malignancies. The extracellular domain of HER2 (HER2-ECD) has been extensively employed as an important target in passive and active immunotherapy. Isolated recombinant prokaryotic HER2-ECD subdomains were previously ...  Read More

Original Article
4. Reduced IFN-γ Production in Chronic Brucellosis Patients

Ehsanollah Ghaznavi-Rad; Khadijeh Khosravi; Nader Zarinfar; Ghasem Mosayebi

Volume 14, Issue 3 , Summer 2017, Pages 215-222

  Background: Brucella is a well-known intracellular bacterium entailing acute and chronic illnesses in humans and domestic animals. The infection chronicity may be affected by the cell-mediated immunity and cytokine patterns. Objective: To evaluate the patterns of T-helper cytokines in patients suffering ...  Read More

Original Article
5. Association of Human Leukocyte Antigens Class I & II with Graves’ Disease in Iranian Population

Zahra Mehraji; Ali Farazmand; Alireza Esteghamati; Sina Noshad; Maryam Sadr; Somayeh Amirzargar; Mir Saeed Yekaninejad; Aliakbar Amirzargar

Volume 14, Issue 3 , Summer 2017, Pages 223-230

  Background: Graves’ disease (GD), a highly rampant autoimmune disorder of the thyroid gland, is responsible for 60-80% of the clinical cases of hyperthyroidism. Over the past decades, genetic association studies have identified several GD susceptibility loci in CTLA-4, TSHR and major histocompatibility ...  Read More

Original Article
6. Combination of Myelin Basic Protein Gene Polymorphisms with HLA-DRB1*1501 in Iranian Patients with Multiple Sclerosis

Parham Nejati; Marzieh Attar; Maryam Rahimian; Davood Fathi; Majid Shahbazi

Volume 14, Issue 3 , Summer 2017, Pages 231-239

  Background: Multiple sclerosis (MS), as a multifactorial autoimmune disease with complex genetic basis, causes demyelination in the central nervous system via cytokine responses to myelin antigens. Myelin basic protein (MBP) is the main protein component of the myelin sheath. HLA-DRB (human leukocyte ...  Read More

Original Article
7. Human Leukocyte Antigen Class I and II Variants in Yemeni Patients with Chronic Renal Failure

Mogahid Yahi'a Nassar; Hassan Abdulwahab Al-Shamahy; Abdullah Saleh Al-Samawi; Nagieb Waza'a Abu Asba; Ibrahiem Husain El-Nono; Haitham Abdulwahab Masood

Volume 14, Issue 3 , Summer 2017, Pages 240-249

  Background: Human leukocyte antigens (HLAs) are found to be significant genetic factors concerning the susceptibility of an individual to certain diseases. Objective: To determine the association between variants of class I (A and B) and class II (DRB1) HLA alleles and chronic renal failure (CRF), compared ...  Read More

Short Paper
8. Poly I:C Delivery into J774.1 & RAW264.7 Macrophages Induces Rapid Cell Death

Cheah Wen Yapp; Amal Widaad Mohaimin; Adi Idris

Volume 14, Issue 3 , Summer 2017, Pages 250-256

  Background: Cytosolic double-stranded RNA (dsRNA) is an important ‘molecular signature’ for the detection of intracellular viral infections. Although intracellular dsRNA is a known potent inducer of apoptosis, the optimal time and dose for the onset of dsRNA-mediated apoptosis have not been ...  Read More