Volume 17 (2020)
Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)
Review Article
1. The Cerebrospinal Fluid Presentations of Neuro-Bechet Disease, a Way to Know ‎the Etiopathogenesis and Improve Armamentarium‎

Shubhasree Banerjee; Kamel Hamzaoui; Anahid Safari; Afshin Borhani-Haghighi

Volume 18, Issue 3 , Summer 2021, Pages 170-178


  Neuro-Behcet's disease (NBD) is a rare but potentially fatal manifestation of Behcet's disease. Common presentations of neuro-Behcet's disease are parenchymal (brainstem and hemispheric manifestations, meningoencephalitis, spinal cord lesions) and non-parenchymal (arterial occlusions, aneurysms, Dural ...  Read More

Original Article
2. Evaluation of CD4+/CD25+/high/CD127low/- Regulatory T Cells in Rheumatoid Arthritis Patients

Samaneh Delavari; Mehri Ghafourian; Elham Rajaei; Karim Mowla; Ata Ghadiri

Volume 18, Issue 3 , Summer 2021, Pages 179-187


  Background: Rheumatoid arthritis (RA) is the most common rheumatoid disease of unknown etiology, determined by the articular cartilage destruction and bone loss. The hallmark of RA is the defect in immune tolerance. Regulatory T cells (Treg) play a critical role in the protection of peripheral tolerance. ...  Read More

Original Article
3. The Regulation of the IL-18 on Group 2 Innate Lymphoid Cells in Allergic Rhinitis

Chuling Li; Yaxiong Xu; Xianglin Luo; Fajian Chen

Volume 18, Issue 3 , Summer 2021, Pages 188-194


  Background: Group 2 innate lymphoid cells (ILC2s) promote allergic inflammation by producing interleukin-4 (IL-4), IL-5, IL-9, and IL-13. IL-18 can promote T helper 2 cell (Th2) response by inducing IL-4, and IL-13 production from mast cells and basophils. However, the regulation of IL-18 on ILC2s remained ...  Read More

Original Article
4. Expression of interleukin-35 and type 2 cytokines in children with acute allergic asthma

Zhangqiao Cai; Xuxia He; Jing Yang

Volume 18, Issue 3 , Summer 2021, Pages 195-202


  Background: Allergic asthma is believed to be a T helper 2 cell (Th2) preponderant response caused by airway hyper-responsiveness. Interleukin-35 (IL-35) is a newly discovered anti-inflammatory cytokine. Objective: To determine whether the expression of IL-35 is associated with type-2 inflammation in ...  Read More

Original Article
5. Pathogenic characteristics of Th17 cells based on IL-17 signaling pathway in regulation of sebaceous gland lipoprotein metabolism in acne rat model

Yanni He; Qiaorong Yang; Tong Zhang; Yibin Zeng; Lingbo Du; Wuqing Wang

Volume 18, Issue 3 , Summer 2021, Pages 203-209


  Background: Acne is a common and chronic inflammatory dermatosis of sebaceous gland units of the human hair follicle. Acne is closely related to immune cytokines and cells including T helper 17cells (Th17 cells). Mis-regulated glycolipid metabolism also plays a vital role in the process. Objective: This ...  Read More

Original Article
6. The association between the decreased expression levels of FOXJ1 and the activation of NF-κB pathway in interstitial lung disease of MRL/Lpr mice

Xueqin Wang; Yingying Gao; Xingyu Ge; Zhifeng Gu

Volume 18, Issue 3 , Summer 2021, Pages 210-219


  Background: Pulmonary manifestations of systemic lupus erythematosus (SLE) are appearing in 4-5% of patients involving lung in almost half of the cases during the disease course. Objective: We compared the autoimmune pulmonary inflammation in the lung tissue of mice to determine the association between ...  Read More

Original Article
7. Mast Cell Numbers in Primary Eosinophilic Colitis are Significantly Higher than in Secondary Tissue Eosinophilia and Normal Controls: a Possible Link to Pathogenesis

Heyam Awad; Ammar Sfaira; Yousef Abu Osba; Mohammad Shahin; Yousef Al- Asa'd; Nooredeen Isbeih; Maha Shomaf; Wasan Hayagneh

Volume 18, Issue 3 , Summer 2021, Pages 220-229


  Background: Primary Eosinophilic Colitis (PEC) is one of the rare eosinophilic gastrointestinal diseases with a poorly understood pathogenesis. Eosinophilic esophagitis (EE) is the most common and best-understood disease in this category. Activated mast cells (MCs) have a role to play in the tissue damage ...  Read More

Original Article
8. Overall status of Epstein-Barr virus infection, IFN-α, and TLR-7/9 in patients with Systemic Lupus Erythematosus

Sayed Mahdi Marashi; Shima Izadi; Seyed Reza Najafizadeh; Ahmad Nejati; Majid Teymoori-Rad; Shohreh Shahmahmoodi; Forough Golsaz-Shirazi; Fazel Shokri

Volume 18, Issue 3 , Summer 2021, Pages 230-240


  Background: Systemic lupus erythematous (SLE) is a multisystem autoimmune disorder. While studying the pathogenesis of SLE is prevalent, both infectious and non-infectious elements are regarded to exert an important impact on the disease's development. Objective: To explore the overall status of EBV, ...  Read More

Original Article
9. Interleukin-10 Promoter and the CCR5 Polymorphisms in Iranian Azari Population with Multiple Sclerosis

Mohammad Asgharzadeh; Davoud Sanajou; Hossein Samadi Kafil; Mehdi Farhoudi; Daryoush Savadi Oskouei; Fatemeh Khaki-Khatibi; Fatemeh Ahmadi; Manouchehr Fadaee; Ali Vegari; Vahid Asgharzadeh; Jalil Rashedi; Behroz Mahdavi Poor; Pourya Gholizadeh

Volume 18, Issue 3 , Summer 2021, Pages 241-248


  Background: Changes in the expression of cytokines as the result of the single nucleotide polymorphisms (SNPs), can affect the incidence of multiple sclerosis (MS). Objective: To investigate the relationship between the frequencies of interleukin-10 (IL-10)-1082 A/G (rs1800896) and CCR5-delta32 genotypes ...  Read More

Original Article
10. Association of three functional polymorphisms in the NLRP3 gene with susceptibility to rheumatoid arthritis in Iranian population

Mehrdad Nasrollahzadeh Sabet; Navid Nasrabadi; Zahra Jalili; Bahram Pakzad; Saeideh Davar; Naeim Ehtesham; Sima Jafarpour; Meysam Mosallaei; Emran Esmaeilzadeh

Volume 18, Issue 3 , Summer 2021, Pages 249-258


  Background: Rheumatoid arthritis (RA) is a complex systemic autoimmune disorder with multifactorial nature. Numerous previous studies have shown that several genes are involved in the pathogenesis and increased risk of RA. The Nod-like receptor pyrin domain containing 3 (NLRP3) is involved in the regulation ...  Read More

Original Article
11. Changes of Peripheral Blood Lymphocyte Subsets and Immune Function in Children with Henoch-Schonlein Purpura Nephritis

QingXiao Su; LiJun Jiang; Jia Chai; ZhiYan Dou; ZanHua Rong; Xue Zhao; Bo Yu; YuXue Wang; XinLiang Wang

Volume 18, Issue 3 , Summer 2021, Pages 259-267


  Background: Purpuric nephritis is the most common secondary glomerular disease in childhood. Its prevalence in children has been steadily rising in recent years. Objective: To explore the characteristics and pathogenesis of changes in peripheral blood lymphocyte subsets and immune function in children ...  Read More