Volume 20 (2023)
Volume 19 (2022)
Volume 18 (2021)
Volume 17 (2020)
Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)
Review Article
Functional Property and Regulatory Mechanism of Macrophages in Complementary and Alternative Medicine: From Bench to Clinic

Can Hu; Yizhi Zhang; Junjiang Liu; Yanyan You; Fanglong Wu; Hongmei Zhou

Volume 21, Issue 2 , June 2024, Pages 103-120


  Complementary and alternative medicine (CAM) includes a wide range of treatments that are gaining acceptance among the public. It is increasingly being recognized as a viable option for treating various diseases with minimal side effects. Common avenues of this therapy include herbal medicine, acupuncture, ...  Read More

Original Article
Natural Killer Cell Subsets in Tumor Draining Lymph Nodes of Patients with Bladder Cancer and Their Clinical Implications

Ali Ariafar; Erfan Kohansal; Amirhassan Mousania; Zahra Faghih

Volume 21, Issue 2 , June 2024, Pages 121-131


  Background: Natural killer (NK) cells are crucial innate components in anti-tumor immunity. However, the clinical impacts and their phenotypes in bladder cancer (BC) remain unclear.Objective: To assess the clinical significance of NK cell subsets in tumor-draining lymph nodes of patients with BC.Methods: ...  Read More

Original Article
Glycyrrhiza Glabra Extract Modulates Type 1 T Helper (TH1) and Regulatory T Cell-Related Immune Responses in an Animal Model of Breast Cancer

Soheila Yousefi; Pedram Basirjafar; Raziyeh Zandvakili; Javad Masoumi; Nahid Zainodini; Hossein Khorramdelazad; Mahsa Gheitasi; Abdollah Jafarzadeh

Volume 21, Issue 2 , June 2024, Pages 132-146


  Background: It is well-known that TH1 and Treg cells exert anti- and pro-tumorigenic activity, respectively. Thus, TH1 cell suppression together with Treg cell hyperactivation contribute to tumor development. Glycyrrhiza glabra (G. glabra) has various immunomodulatory and anti-tumorigenic properties.Objective: ...  Read More

Original Article
Evaluation of Monocyte Subpopulations in Patients with Systemic Sclerosis and its Association with Clinical Manifestations of the Disease: a Cross-sectional Controlled Study

Elham Safarzadeh; Vahid Asghariazar; Shohreh Pordel; Elham Baghbani; Asgar Fekri; Afsaneh Enteshari-Moghaddam

Volume 21, Issue 2 , June 2024, Pages 147-157


  Background: Systemic sclerosis (SSc) is a chronic autoimmune disorder characterized not only by fibrosis and vasculopathy but also by inflammation. Previous studies have demonstrated monocyte involvement in SSc development, suggesting a role for immune dysfunction in SSc pathogenesis.Objective: To investigate ...  Read More

Original Article
The Effect of Interferon Beta and Natalizumab on miR-20b Expression in Patients with Relapsing-Remitting Multiple Sclerosis is Potentially Mediated by Modulation of the Jak–STAT Signaling Pathway: A Case-control Study

Aysan Jafari Harandi; Alireza Mirzaee Sedigh; Mitra Ataei; Sepideh Bayrami; Emran Esmaeilzadeh; Mohammad Hossein Sanati

Volume 21, Issue 2 , June 2024, Pages 158-165


  Background: The mechanisms of the function of interferon beta (IFN-β) and natalizumab (NTZ) in multiple sclerosis (MS) patients have not yet been fully understood. Over the past decades, many studies have been conducted to evaluate gene expression changes especially regulatory non-coding RNAs such ...  Read More

Original Article
Evaluation of PD-1 Gene Expression Profile and Methylation of the Regulatory Regions in Patients with Ankylosing Spondylitis

Narjes Soleimanifar; Sara Assaadiasl; Mohammed Sameer Al-Shammari; Abdol-Rahman Rostamian; Maryam Sadr; Sepideh Shahkarami; Hanieh Mojtahedi; Mohammad Hossein Nicknam

Volume 21, Issue 2 , June 2024, Pages 166-175


  Background: Ankylosing spondylitis (AS) is a chronic autoimmune disorder characterized by the fusion of vertebral joints and axial arthritis. The programmed death-1 (PD-1) inhibitory receptor has a pivotal role in controlling T cell function and may have a significant impact on the pathogenesis of ...  Read More

Case Report
Outcome of Cyclophosphamide Treatment Following Hematopoietic Stem Cell Transplantation in a Thalassemia Patient: A Case Study

Heba M. Bahlol; Sohaila M. Khalil; Mohamed R. El-Shanshory; Mohamed L. Salem

Volume 21, Issue 2 , June 2024, Pages 176-183


  Hematopoietic stem cell transplantation (HSCT) is the only curative therapy for β-thalassemia major in children. However, it often induces graft-versus-host-disease (GVHD), which is associated with complications. In the present study, we used cyclophosphamide (Cy) to treat a thalassemia patient ...  Read More

Letter To The Editor
Letter to the Editor Regarding “Comparative Immunogenicity and Neutralization Potency of Four Approved COVID-19 Vaccines in BALB/c Mice”

Hineptch Daungsupawong; Viroj Wiwanitkit

Volume 21, Issue 2 , June 2024, Pages 184-185


  Dear EditorWe are writing to discuss the article titled “Comparative Immunogenicity and Neutralization Potency of Four Approved COVID-19 Vaccines in BALB/c Mice” (1). The study examined the immunogenicity and neutralization efficacy of four COVID-19 vaccines licensed in Iran in BALB/c mice. ...  Read More