Volume 18 (2021)
Volume 17 (2020)
Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)
1. Serological and Molecular Tests for COVID-19: a recent update

Amir Hossein Mansourabadi; Mona Sadeghalvad; Hamid-Reza Mohammadimotlagh; Aliakbar Amirzargar

Volume 18, Issue 1 , Winter 2021, , Pages 13-33


  The COVID-19 pandemic is probably the most devastating worldwide challenge in recent century. COVID-19 leads to a mild to severe respiratory disease and affects different organs and has become a global concern since December 2019. Meanwhile, molecular biology and diagnostic laboratories played an essential ...  Read More

2. HLA Class I and Class II Genes Distribution of the Sistanis in Iran

mahdi aminikhah; Mir Saeed Yekaninejad; M.Hosein Nicknam; Farideh Khosravi; Mehrnaz naroei nejad; Bita Ansaripour; batol moradi; Behrouz Nikbin; Aliakbar Amirzargar

Volume 15, Issue 2 , Spring 2018, , Pages 97-111


  Background: The high polymorphism in the human leukocyte antigen (HLA) genes can be used as an identity of individuals to compare with other populations. This extreme polymorphism in the HLA system is accountable for the differences in alleles and haplotypes among ethnic groups, populations, and the ...  Read More

3. Association of Human Leukocyte Antigens Class I & II with Graves’ Disease in Iranian Population

Zahra Mehraji; Ali Farazmand; Alireza Esteghamati; Sina Noshad; Maryam Sadr; Somayeh Amirzargar; Mir Saeed Yekaninejad; Aliakbar Amirzargar

Volume 14, Issue 3 , Summer 2017, , Pages 223-230

  Background: Graves’ disease (GD), a highly rampant autoimmune disorder of the thyroid gland, is responsible for 60-80% of the clinical cases of hyperthyroidism. Over the past decades, genetic association studies have identified several GD susceptibility loci in CTLA-4, TSHR and major histocompatibility ...  Read More

4. Increased Expression of Toll-Like Receptors 2 and 4 in Renal Transplant Recipients that Develop Allograft Dysfunction: A Cohort Study

Morteza Hosseinzadeh; Mohsen Nafar; Pedram Ahmadpoor; Farshid Noorbakhsh; Mir Saeed Yekaninejad; Mohammad Hossein Niknam; Aliakbar Amirzargar

Volume 14, Issue 1 , Winter 2017, , Pages 24-34

  Background: The incidence of ischemic reperfusion injury (IRI) in early phase post-transplantation and activation of toll-like receptor (TLR-2) and TLR-4 remarkably impact the outcome of a renal allograft. Objective: To investigate whether the expression of TLRs in peripheral blood mononuclear cells ...  Read More

5. Effect of TNF-α Blockade in Gingival Crevicular Fluid on Periodontal Condition of Patients with Rheumatoid Arthritis

Zeinab Kadkhoda; Aliakbar Amirzargar; Zahra Esmaili; Mahdi Vojdanian; Solmaz Akbari

Volume 13, Issue 3 , Summer 2016, , Pages 197-203

  Background: Periodontitis and rheumatoid arthritis (RA) share a number of clinical and pathologic features, one of which is the presence of the tumor necrosis factor alpha (TNF-α)-induced bone resorption that is involved in the pathogenesis of both. Objectives: To investigate the effect of TNF-α ...  Read More

6. Altered Suppressor Function of Regulatory T Cells in Type 1 Diabetes

Babak Aghili; Ali Akbar Amirzargar; Asadollah Rajab; Ali Rabbani; Arya Sotoudeh; Sara Assadiasl; Bagher Larijani; Ahmad Massoud

Volume 12, Issue 4 , Autumn 2015, , Pages 240-251

  Background: Type 1 diabetes (T1D) is a T cell mediated autoimmune disease targeting the insulin-producing β cells within pancreatic islets. Autoimmune diseases may develop as a consequence of altered balance between regulatory (Tregs) and autoreactive T cells. Objectives: To evaluate Treg cells ...  Read More

7. Reference Values of Lymphocyte Sub-Populations in Healthy Human Immunodeficiency Virus-Negative Iranian Adults

Atefeh Kamallou; Mahbobeh Haji Abdolbaghi; Minoo Mohraz; Mernaz Rasolinejad; Ehsan Karbasi; Bita Ansaripour; Samaneh Soltani; Arezou Rezaei; Neda Khalili; Aliakbar Amirzargar

Volume 11, Issue 4 , Autumn 2014, , Pages 221-232

  Background: Lymphocyte subsets enumeration is considered prominent in the management of primary and acquired immunodeficiency disorders. Because of local variations due to race, age, gender, and environmental conditions on lymphocyte subsets, and to improve the accuracy of interpretation of laboratory ...  Read More

8. Regulatory T Cell Subtypes and TGF-β1 Gene Expression in Chronic Allograft Dysfunction

Sara Assadiasl; Pedram Ahmadpoor; Mohsen Nafar; Mahboob Lessan Pezeshki; Fateme Pourrezagholi; Mahmoud Parvin; Abtin Shahlaee; Adel Sepanjnia; Mohammad Hossein Nicknam; Aliakbar Amirzargar

Volume 11, Issue 3 , Summer 2014, , Pages 139-152

  Background: Regulatory T cells have been suggested to have a protective role against acute rejection in allograft recipients. However, there is little information available about their contribution to chronic rejection process. The role of transforming growth factor-beta 1 (TGF- β1) as a profibrogenic ...  Read More

9. Association between HLA-DQB1*03:01 and Bullous Pemphigoid in Iranian Patients

Nafiseh Esmaili; Hossein Mortazavi; Sheyda Chams-Davatchi; Maryam Daneshpazhoooh; Maede Rayati Damavandi; Zeinab Aryanian; Ali Akbar Amirzargar

Volume 10, Issue 1 , Winter 2013, , Pages 1-9

  Background: A common Human Leukocyte Antigen (HLA) class II allele, DQβ1*03:01, seems to be associated with Bullous pemphigoid (BP) in Caucasians whereas previous studies in other ethnic groups showed other HLA class II alleles as genetic predisposing factors for BP. Objective: To investigate the ...  Read More

10. Anti-HLA Antibodies and Kidney Allograft Outcomes in Recipients with Donor Bone Marrow Cell Infusion

Ghasem Solgi; Gholamreza Pourmand; Abdorasool Mehrsai; Mohsen Tahei-mahmoudi; Mohammad Hossein Nicknam; Mohammad Ebrahimi Rad; Ali Seraji; Amirabbas Asadpoor; Bita Ansaripor; Behrouz Nikbin; Aliakbar Amirzargar

Volume 7, Issue 1 , Winter 2010, , Pages 18-29

  Background: Anti-HLA-antibodies are known to affect the allograft survival in transplant recipient patients. Objective: The aim of this study was to evaluate the association between anti-HLA antibodies and kidney allograft outcomes, particularly in recipients with concur-rent donor bone marrow cell infusion ...  Read More

11. HLA-DRB1, DQA1 and DQB1 Alleles and Hap-lotypes Frequencies in Iranian Healthy Adult Responders and Non-Responders to Recombi-nant Hepatitis B Vaccine

Ali Akbar Amirzargar; Nilufar Mohseni; Mohammad Ali Shokrgozar; Zohreh Arjang; Nahid Ahmadi; Manijeh Yousefi Behzadi; Amir Amanzadeh; Fazel Shokri

Volume 5, Issue 2 , Spring 2008, , Pages 92-99

  Background: Different studies have demonstrated that a small proportion of healthy individuals receiving the hepatitis B (HB) vaccine do not produce protective levels of anti-HB antibody, a phenomenon which could be linked to certain human leukocyte an-tigen (HLA) class-II alleles or haplotypes. Objectives: ...  Read More

12. Angiotensin Converting Enzyme Gene Polymorphism in Iranian Patients with Type 2 Diabetes

Abdol Rahim Nikzamir; Taghi Golmohammadi; Manouchehr Nakhjavani; Mahine Zahraei; Ali Akbar Amirzargar

Volume 3, Issue 1 , Winter 2006, , Pages 23-29

  Background: Angiotensin I converting enzyme (ACE) is a Zinc metalloproteinase, converts Ang-I to Ang- II, a pro-inflammatory agent which may contribute to pathophysiology of some diseases like type 2 diabetes. Objective: To investigate the relationship between ACE I/D polymorphism and type 2 diabetes ...  Read More

13. Deficient Expression of Bruton's Tyrosine Kinase in Monocytes from X-Linked Agammaglobulinemia as Evaluated by a Flow Cytometric Analysis and its Clinical Application to Carrier Detection

Asghar Aghamohammadi; Ali Akbar Amirzargar; Nima Parvaneh; Paul Marjousef; Mostafa Moin; Abdolhassan Farhoudi; Mehdi Yeganeh; Toshio Miyawaki

Volume 2, Issue 4 , Autumn 2005, , Pages 201-207

  Background: The B-cell defect in X-linked agammaglobulinemia (XLA) is caused by mutations in the gene for Bruton's tyrosine kinase (BTK). BTK mutations result in deficient expression of BTK protein in peripheral blood monocytes. Methods: Using the anti-BTK monoclonal antibody (48-2H), a flow cytometric ...  Read More

14. Prediction of Rejection in Renal Transplantation by Immune Parameters

Mahboob Lessan-Pezeshki; Ali Akbar Amirzargar; Nooshin Golabi; Mohammadreza Khatami; Behzad Einollahi; Vahid Pourfarziani; Farideh Khosravi; Hassaneh Tajerzadeh; Behrouz Nikbin

Volume 2, Issue 2 , Spring 2005, , Pages 87-90

  Background: Monitoring of phenotypic characteristics of T-lymphocytes in peripheral blood is commonly performed to give the clinical parameters in the management of kidney transplant recipients.   Objective: To predict rejection in renal transplantation by immune parameters. Methods: 16 non-diabetic ...  Read More

15. Cytokine Gene Polymorphisms in Iranian Patients with Beta-Thalassemia Major

Morteza Bagheri; Ali Akbar Amirzargar; Ardeshir Ghavamzadeh; Kamran Alimoghadam; Farideh Khosravi; Bita Ansaripour; Batoul Moradi; Behrouz Nikbin

Volume 2, Issue 1 , Winter 2005, , Pages 43-49

  Background: β-thalassemia as a hereditary disease is defined as defective synthesis of   β-globin chains, resulting in erythropoiesis abnormalities and severe anemia. Different studies have shown that cytokines and cytokine gene polymorphisms play a major role in the pathogenesis of   ...  Read More

16. Microchimerism and Renal Transplantation: Doubt Still Persists

Behrouz Nikbin; Nader Tajik; Ali Saraji; Gholam Reza Pourmand; Fatemeh Talebian; Abdurasul Mehrsai; Ali Akbar Amirzargar

Volume 1, Issue 3 , Autumn 2004, , Pages 162-168

  Background: The Presence of donor leukocytes in recipients of organ allograft has been shown even several years after transplantation. However, it remains unclear whether this donor cell microchimerism plays an effective role in allograft acceptance or is simply a consequence of immunosuppressive conditions ...  Read More

17. Cytokines Genes Polymorphisms in Iranian Patients with Pulmonary Tuberculosis

Ali Akbar Amirzargar; Abdol Ali Danesh; Farideh Khosravi; Mohammad Hossein Niknam; Behrouz Nikbin

Volume 1, Issue 2 , Summer 2004, , Pages 125-129

  Background: Pulmonary tuberculosis (PTB) has recently become a major problem in developed countries especially in immune compromised HIV infected individuals. Cytokines, their genes and receptors have been implicated in the protective immunity, pathophysiology and development of tuberculosis.   ...  Read More

18. Association of IFN-¹ Gene Polymorphism with Type 1 Diabetes in Iranian Patients

Ali Rafinejad; Mohammad Hossein Niknam; Ali Akbar Amirzargar; Farideh Khosravi; Forouzan Karimi; Bagher Larijani

Volume 1, Issue 2 , Summer 2004, , Pages 130-132

  Background: Type 1 Diabetes (T1D) is a chronic and progressive autoimmune disorder. Cytokines play a critical role in the pathogenesis of T1D.   Objective: IFN-¹ polymorphism was investigated in T1D and compared with normal controls.   Methods: Thirty patients suffering from T1D and 40 ...  Read More

19. Th1 and Th2 Cytokine Gene Polymorphism in Iranian Patients with Chronic Myelogenous Leukemia

Ali Akbar Amirzargar; Morteza Bagheri; Ardeshir Ghavamzadeh; Kamran Alimoghadam; Farideh Khosravi; Mohammad Hossein Nicknam; Mandana Moheydin; Bita Ansaripour; Batul Moradi; Behrouz Nikbin

Volume 1, Issue 1 , Spring 2004, , Pages 26-33

  Background:It has been hypothesized that genetic factors other than histocompatibility disparity may play a role in predisposition to developing Chronic Myelogenous Leukemia (CML). In this regard, Th1 and Th2 cytokines and their gene polymorphism seems to be important. Overall expression and secretion ...  Read More