Volume 18 (2021)
Volume 17 (2020)
Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)
2. Rapamycin Inhibits Expansion of Cord Blood Derived NK and T Cell

Monireh Zare; Behnaz Valipour; Seyede Momeneh Mohammadi; Mohammad Nouri; Aliakbar Movassaghpour; Hojjatollah Nozad Charoudeh

Volume 14, Issue 3 , Summer 2017, , Pages 192-199

  Background: The mammalian target of rapamycin (mTOR) is important in hematopoiesis. Despite the central role of mTOR in regulating the differentiation of immune cells, the effect of mTOR function on cord blood mononuclear cells is yet to be defined. Objectives: To evaluate the effect of mTOR inhibition, ...  Read More

3. The Effect of Safranal on Th1/Th2 Cytokine Balance

Reza Feyzi; Mohammad Hossein Boskabady; Seyedeh Masoumeh Seyed hosseini Tamijani; Houshang Rafatpanah; Seyed Abdolrahim Rezaei

Volume 13, Issue 4 , Autumn 2016, , Pages 263-273

  Background: Several biological and medical benefits of Saffron, Crocus sativus (Iridaceae), have been demonstrated. However, mechanisms of actions for purified constituents are greatly unknown. Objective: To examine the effects of Safranal, a main constituent of Saffron stigma, on cell viability and ...  Read More

4. Identification of the Rare, Four Repeat Allele of IL-4 Intron-3 VNTR Polymorphism in Indian Populations

Henu Kumar Verma; Aditya Nath Jha; Prafulla Kumar khodiar; Pradeep Kumar Patra; Lakkakula Venkata Kameswara Subrahmanya Bhaskar

Volume 13, Issue 2 , Spring 2016, , Pages 124-131

  Background: Cytokines are cell signaling molecules which upon release by cells facilitate the recruitment of immune-modulatory cells towards the sites of inflammation. Genetic variations in cytokine genes are shown to regulate their production and affect the risk of infectious as well as autoimmune diseases. ...  Read More

5. CD26+ Cord Blood Mononuclear Cells Significantly Produce B, T, and NK Cells

Zeynab Aliyari; Forogh Alemi; Balal Brazvan; Hamid Tayefi Nasrabadi; Hojjatollah Nozad Charoudeh

Volume 12, Issue 1 , Winter 2015, , Pages 16-26

  Background: Umbilical cord blood (UCB) is an alternative source of hematopoietic stem cell transplantation (HSCT), used in Leukemia treatment. CD26+ cells, a fraction of CD34 positive cells, are a major population of UCB cells which negatively regulate the in vivo homing and engraftment of HSCs. CD26 ...  Read More

6. Differences in the Expression of TLRs and Inflammatory Cytokines in Pre-Eclamptic Compared with Healthy Pregnant Women

Feryal Dabagh-Gorjani; Fahimeh Anvari; Jaleh Zolghadri; Eskandar KamaliSarvestani; Behrouz Gharesi-Fard

Volume 11, Issue 4 , Autumn 2014, , Pages 233-245

  Background: Preeclampsia (PE) is one of the most complex and life-threatening pregnancy disorders and is considered as a major cause of mortality among mothers and fetuses worldwide. Although the exact etiology of PE is not well known several lines of evidence support an immunological etiology for PE. ...  Read More

7. Analysis of Serum Cytokine Levels in Larynx Squamous Cell Carcinoma and Dysplasia Patients

Mete Eyigor; Hulya Eyigor; Ustun Osma; MustafaDeniz Yilmaz; Nuray Erin; Omer Tarik Selcuk; Cem Sezer; Meral Gultekin; Sadi Koksoy

Volume 11, Issue 4 , Autumn 2014, , Pages 259-268

  Background: Although the imbalance of cytokines in Head and Neck Squamous Cell Carcinoma (HNSCC) is well known, there is scarce data regarding its occurrence during dysplasia, before the malignant transformation. Objective: To determine whether laryngeal dysplasia patients show a different cytokine profile ...  Read More

8. IL-6, IL-10 and IL-17 Gene Polymorphisms in Iranian Women with Recurrent Miscarriage

Motahareh Bahadori; Saeed Zarei; Amir Hassan Zarnani; Omid Zarei; Farah Idali; Reza Hadavi; Mahmood Jeddi-Tehrani

Volume 11, Issue 2 , Spring 2014, , Pages 97-104

  Background: Pro-inflammatory and anti-inflammatory cytokines and polymorphisms of their genes have been described to be involved in the pathogenesis of recurrent miscarriage (RM). Objective: To investigate the association between RM and five polymorphisms of cytokine genes, interleukin 10 (IL-10), (-592 ...  Read More

9. Negative Association of Serum IL-6 and IL-17 with Type-II Diabetes Retinopathy

Nadeem Afzal; Shakeela Zaman; Aneela Asghar; Khursheed Javed; Faheem Shahzad; Abu Zafar; Abdul Hanan Nagi

Volume 11, Issue 1 , Winter 2014, , Pages 40-48

  Background: Diabetes mellitus (DM) is a health concern which leads to complications such as retinopathy. Pakistan has 6.9 million people living with DM and this toll will be doubled by 2025. Objective: To determine serum IL-6 and IL-17 of type 2 diabetes mellitus (T2DM) patients with retinopathy. Methods: ...  Read More

10. Immune Deviation in Recurrent Vulvovaginal Candidiasis: Correlation with Iron Deficiency Anemia

Nadereh Naderi; Zahra Etaati; Mansoreh Rezvani Joibari; Seyed Alireza Sobhani; Said Hosseni Tashnizi

Volume 10, Issue 2 , Spring 2013, , Pages 118-126

  Background: Iron Deficiency Anemia (IDA) has been controversially linked to IL-4 production in previous studies. A predominant Th1 response leads to resistance against recurrent vulvovaginal candidiasis (RVVC), whereas a Th2 response exacerbates the disease. Objective: To investigate the possible effect ...  Read More

11. A Clinical Randomized Trial on Endocervical Inflammatory Cytokines and Betamethasone in Prime-Gravid Pregnant Women at Risk of Preterm Labor

Soghra Khazardoust; Pouya Javadian; Bahram Salmanian; Farnaz Zandevakil; Fatemeh Abbasalizadeh; Shohreh Alimohamadi; Sedigheh Borna; Tooba Ghazanfari; Sedigheh Hantoushzadeh

Volume 9, Issue 3 , Summer 2012, , Pages 199-207

  Background: There are strong evidences suggesting the secretion of different cytokines in cervical fluid during preterm labor. Betamethasone is widely administered for several reasons in preterm conditions. Objective: To Investigate the possible effect of betamethasone on endocervical cytokine concentration ...  Read More

12. Cytokine Profile in the Endometrium of Normal Fertile and Women with Repeated Implantation Failure

Samira Rajaei; Amir Hassan Zamani; Mahmood Jeddi-Tehrani; Maryam Tavakoli; Afsaneh Mohammadzadeh; Ali Dabbagh; Mahroo Mirahmadian

Volume 8, Issue 4 , Autumn 2011, , Pages 201-208

  Background: Repeated Implantation Failure (RIF) is one of the most intricate obstacles in assisted reproduction. The cytokine and chemokine composition of uterine cavity seem to play important roles in the implantation process. Objective: To compare the cytokine profile in the endometrium of normal fertile ...  Read More

13. Effect of Surgical Flap on IL-1β and TGF-β Concentrations in the Gingival Crevicular Fluid of Patients with Moderate to Severe Chronic Periodontitis

Mandana Sattari; Alireza Fathiyeh; Fatemeh Gholami; Hassan Darbandi Tamijani; Mahdi Ghatreh Samani

Volume 8, Issue 1 , Winter 2011, , Pages 20-26

  Background: Growth factors play a major part in wound healing in many tissues including the periodontium. Transforming growth factor-β1 (TGF-β1) is one of these factors present in the gingival crevicular fluid. In addition, it is considered as one of the most important anti-inflammatory cytokines. ...  Read More

14. Brucella abortus L7/L12 Recombinant Protein Induces Strong Th1 Response in Acute Brucellosis Patients

Esra Kazak; Sergio Costa Oliveria; Güher Goral; Halis Akalin; Emel Yilmaz; Yasemin Heper; Haluk Barbaros Oral

Volume 7, Issue 3 , Summer 2010, , Pages 132-141

  Background: Because of high morbidity of the brucellosis in humans and the potential use of the microorganism as an agent of biologic warfare, protection of effective vaccines and specific diagnostic reagents become necessary to eradicate brucellosis. Objective: In this study we aimed to investigate ...  Read More

15. The Predictive Value of HLA-DR Matching and Cytokine Gene Polymorphisms in Renal Allograft Acute Rejection: A Living-unrelated Donor (LURD) Study

Nader Tajik; Tohid Kazemi; Aliakbar Delbandi; Ahad Ghods; Alireza Salek Moghaddam

Volume 3, Issue 4 , Autumn 2006, , Pages 150-156

  Background: In addition to Human Leukocyte Antigens (HLA) compatibility, gene polymorphisms in cytokines might also be important in the quality of allogeneic immune response. Objective: To evaluate the influence of HLA-DR matching and a number of cytokine gene polymorphisms on acute rejection after living-unrelated ...  Read More

16. Study of Chenopodium Album Allergenic Extract to Induce Allergic Asthma in Murine Model

Tahereh Mousavi; Nahid Asadi; Majid Tebyanian

Volume 2, Issue 3 , Summer 2005, , Pages 166-171

  Background: The incidence of allergic and asthmatic diseases has been continuously increased in both industrial and developing countries. Extracts from various known allergens are used for the diagnostic and therapeutic purposes. Objective: To investigate the effects of an extract prepared from Chenopodium ...  Read More

17. Prediction of Rejection in Renal Transplantation by Immune Parameters

Mahboob Lessan-Pezeshki; Ali Akbar Amirzargar; Nooshin Golabi; Mohammadreza Khatami; Behzad Einollahi; Vahid Pourfarziani; Farideh Khosravi; Hassaneh Tajerzadeh; Behrouz Nikbin

Volume 2, Issue 2 , Spring 2005, , Pages 87-90

  Background: Monitoring of phenotypic characteristics of T-lymphocytes in peripheral blood is commonly performed to give the clinical parameters in the management of kidney transplant recipients.   Objective: To predict rejection in renal transplantation by immune parameters. Methods: 16 non-diabetic ...  Read More

18. Cytokines Genes Polymorphisms in Iranian Patients with Pulmonary Tuberculosis

Ali Akbar Amirzargar; Abdol Ali Danesh; Farideh Khosravi; Mohammad Hossein Niknam; Behrouz Nikbin

Volume 1, Issue 2 , Summer 2004, , Pages 125-129

  Background: Pulmonary tuberculosis (PTB) has recently become a major problem in developed countries especially in immune compromised HIV infected individuals. Cytokines, their genes and receptors have been implicated in the protective immunity, pathophysiology and development of tuberculosis.   ...  Read More

19. Association of IFN-¹ Gene Polymorphism with Type 1 Diabetes in Iranian Patients

Ali Rafinejad; Mohammad Hossein Niknam; Ali Akbar Amirzargar; Farideh Khosravi; Forouzan Karimi; Bagher Larijani

Volume 1, Issue 2 , Summer 2004, , Pages 130-132

  Background: Type 1 Diabetes (T1D) is a chronic and progressive autoimmune disorder. Cytokines play a critical role in the pathogenesis of T1D.   Objective: IFN-¹ polymorphism was investigated in T1D and compared with normal controls.   Methods: Thirty patients suffering from T1D and 40 ...  Read More