Volume 18 (2021)
Volume 17 (2020)
Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 1 (2004)
Original Article
1. Monoclonal Antibodies as Therapeutic Agents: Advances and Challenges

Helmout Modjtahedi

Volume 2, Issue 1 , Winter 2005, Pages 3-20

  Despite the major advances in conventional forms of treatment (i.e. surgical techniques, radiotherapy and chemotherapy) and improved survival rates, cancer is still the second leading cause of death in developing countries. One major limitation of cytotoxic drugs and radiation in the treatment of cancer ...  Read More

Original Article
2. Comparison of Functional Competence of Umbilical Cord and Adult Peripheral Blood Dendritic Cells in Allogenic Mixed Leukocyte Reaction

Nahid Naderi; Ali Akbar Pourfathoolah; Mahin Nikougoftar; Kamran Alimoghadam; Ardeshir Ghavamzadeh; Seyed Mohammad Moazzeni

Volume 2, Issue 1 , Winter 2005, Pages 21-28

  Background: Dendritic cells (DCs) are the most potent stimulators of primary T cell responses and play a key role in immune reactions after stem cell transplantation. Very little is known about the cord blood (CB) dendritic cells and their potential involvement in the low incidence and lower severity ...  Read More

Original Article
3. The Influence of Perforin Expression on the Sensitivity of LAK/NK Killing Against Various Tumor Target Cells

Zahra Amirghofran

Volume 2, Issue 1 , Winter 2005, Pages 29-35

  Background: Perforin is known to be important in cytolytic activity mediated by natural killer (NK) cells.   Objective: To study the relationship between the efficiency of NK and lymphokine-activated killer (LAK) cells activity, and the expression of perforin and HLA class I molecules.   Methods: ...  Read More

Original Article
4. Glycation of Human IgG Induces Structural Alterations Leading to Changes in its Interaction with Anti-IgG

Mohammad Taghi Goodarzi; Safyieh Ghahramany; Mohammad Hossien Mirmomeni

Volume 2, Issue 1 , Winter 2005, Pages 36-42

  Background: Glycation of proteins is a non-enzymatic spontaneous process that occurs in diabetes mellitus and aging, altering the structure and function of proteins. IgG undergoes glycation leading to changes in its reactivity to antigen and fixation of complement.   Objective: This study aimed ...  Read More

Original Article
5. Cytokine Gene Polymorphisms in Iranian Patients with Beta-Thalassemia Major

Morteza Bagheri; Ali Akbar Amirzargar; Ardeshir Ghavamzadeh; Kamran Alimoghadam; Farideh Khosravi; Bita Ansaripour; Batoul Moradi; Behrouz Nikbin

Volume 2, Issue 1 , Winter 2005, Pages 43-49

  Background: β-thalassemia as a hereditary disease is defined as defective synthesis of   β-globin chains, resulting in erythropoiesis abnormalities and severe anemia. Different studies have shown that cytokines and cytokine gene polymorphisms play a major role in the pathogenesis of   ...  Read More

Original Article
6. Maternal Serum Levels of Transforming Growth Factor ß1 (TGF-ß1) in Normal and Preeclamptic Pregnancies

Maryam Ayatollahi; Alamtaj Samsami Dehaghani; Ziaedin Tabei

Volume 2, Issue 1 , Winter 2005, Pages 50-55

  Background: Successful pregnancy in allopregnant women depends upon the control of graft rejection mechanisms. It has been suggested that some immunosuppressive cytokines contribute to successful pregnancy and transplantation. Transforming growth factor beta (TGF-   β) exhibits potent immunoregulatory ...  Read More

Original Article
7. Application of Specific Monoclonal Antibodies for Characterization of Leishmania spp. Promastigotes Using Indirect Immunofluorescent and Immunoperoxidase Tests

Seyed Mahmoud Sadjjadi; Sadreddin Mohseni Ardehali; Reza Adibmanesh; Ezzatollah Basiri

Volume 2, Issue 1 , Winter 2005, Pages 56-62

  Background: Different methods have been used for characterization of Leishmania promastigotes. Monoclonal antibodies are useful in characterization of   Leishmania spp . both amastogotes and promastigotes. Objective: Comparing the characterization of   Leishmania spp. promastigotes with immunoperoxidase ...  Read More

8. A Case of Thymoma with Multiple Autoimmune Presentations

Seyyed Mohammad Ali Ghayumi

Volume 2, Issue 1 , Winter 2005, Pages 63-65

  A 40 year old female presented with a history of cough for 1.5 years and diarrhea for 5 days. She further had a history of pinkish discoloration of skin and red-crusted papules on the anterior and posterior parts of the trunk. Chest X-ray and chest CTScan revealed focal nodular densities in lung besides ...  Read More