Volume 18 (2021)
Volume 17 (2020)
Volume 16 (2019)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)
Original Article
1. Vaccination with Live Attenuated L. Major and TLR4 Agonist Promotes a Th1 Immune Response and Induces Protection against L. Major Infection in BALB/c Mice

Shamsi Noorpisheh Ghadimi; Shirin Farjadian; Gholam Reza Hatam; Mehdi Kalani; Bahador Sarkari

Volume 15, Issue 2 , Spring 2018, Pages 74-83


  Background: Toll like receptors play a major role in immune responses against Leishmania parasites. Objective: To evaluate the efficacy of vaccination with live attenuated L. major and TLR4 agonist in protection against L. major infection. Methods: Attenuated L. major was prepared by continuous sub-culturing ...  Read More

Original Article
2. Anti-inflammatory Effects of PMX205 in Mouse Macrophage Periodontitis Model

Gege Li; Jiahui Pan; Qiuling Tang; Xinchan Liu; Liuran Wang; Yang Meng; Weixian Yu

Volume 15, Issue 2 , Spring 2018, Pages 84-96


  Background: C5areceptor antagonistPMX205 is a synthetic hexapeptidecapable of blocking C5a-C5a receptor (C5aR) axis by simulating C5a active C-terminal amino acid residues. This hexapeptide presents good anti-inflammatory effects in a myriad inflammation models. The anti-inflammatory effect of PMX205 ...  Read More

Original Article
3. HLA Class I and Class II Genes Distribution of the Sistanis in Iran

mahdi aminikhah; Mir Saeed Yekaninejad; M.Hosein Nicknam; Farideh Khosravi; Mehrnaz naroei nejad; Bita Ansaripour; batol moradi; Behrouz Nikbin; Aliakbar Amirzargar

Volume 15, Issue 2 , Spring 2018, Pages 97-111


  Background: The high polymorphism in the human leukocyte antigen (HLA) genes can be used as an identity of individuals to compare with other populations. This extreme polymorphism in the HLA system is accountable for the differences in alleles and haplotypes among ethnic groups, populations, and the ...  Read More

Original Article
4. Association between KIR Genes and Efficacy of Treatment of HBeAg-Positive Chronic Hepatitis B Patients with Entecavir

yunlong zhuang; xixi li; huicong xu; hui ye; di sun; xiangzhng liu; Guijie Ren

Volume 15, Issue 2 , Spring 2018, Pages 112-121


  Background: Entecavir (ETV) is commonly used to treat chronic hepatitis B (CHB) in China. However, certain percentages of e-Antigen (HBeAg) positive CHB patients do not respond to ETV therapy. Objective: To investigate whether the killer immunoglobulin-like receptor (KIR) genes were associated with seroconversion ...  Read More

Original Article
5. Hemin Induces the Activation of NLRP3 Inflammasome in N9 Microglial Cells

Yan Tan; Si-Wei Tan; Bo-Ya Fan; Lei Li; Yuan-Guo Zhou

Volume 15, Issue 2 , Spring 2018, Pages 122-132


  Background: Hemin is an important sterile component that induces a neuroinflammatory response after intracerebral hemorrhage, in which NLRP3 inflammasome activation has also proved to be involved. Although microglial activation acts as a key contributor in the neuroinflammatory response, the relationship ...  Read More

Original Article
6. Identification of hnRNP C1/C2 as an Autoantigen in Patients with Behcet’s Disease

Muhammad Hussain; Jiangshan Xiao; Yixuan Zhang; Peng Chen; Hongwu Du

Volume 15, Issue 2 , Spring 2018, Pages 133-141


  Background: Ribonucleoproteins particles that form the spliceosomes are among the most frequently targeted molecules of the autoimmune response. In the last few years, autoantibodies against all A/B hnRNP proteins have been found in the sera of patients with rheumatoid arthritis (RA), systemic lupus ...  Read More

Original Article
7. Increased Levels of AIM2 and Circulating Mitochondrial DNA in Type 2 Diabetes

Yolanda Cataño Cañizalez; Edith Uresti Rivera; Rocio Garcia Jacobo; Diana Portales Perez; Yadira Bastian; J Rodriguez Rivera; Roberto Gonzalez Amaro; Jose Enciso Moreno; Mariana Garcia Hernandez

Volume 15, Issue 2 , Spring 2018, Pages 142-155


  Background: Chronic inflammation has critical role in Type 2 diabetes (T2D), in which IL-1β contributes in insulin resistance and beta cell dysfunction. The activation of NLRP3 and AIM2 by endogens ligands, such as mtDNA can lead to the release of active form of IL-1β. Objective: To evaluate ...  Read More

Short Paper
8. The Relationship between Plasma Levels of Interleukin-6, Multiple Organ Dysfunction and Mortality in Orthopedic Patients

adel ebrahimpour; Ahamadreza Mirbolook; mohammadali okhovatpour; mohammadreza sajadi; kamyar makvandi; mohamad sadegh mousavi; sepehr saghari; mehrdad sadighi

Volume 15, Issue 2 , Spring 2018, Pages 156-164


  Background: Interleukin 6 (IL-6) functions as both a pro-inflammatory cytokine and an anti-inflammatory cytokine. Objective: To evaluate the levels of IL-6 in patients with multiple organ dysfunction syndrome (MODS). Methods: Level of IL-6 was assessed and recorded for 14 days subsequent to the injury ...  Read More