Volume 19 (2022)
Volume 18 (2021)
Volume 17 (2020)
Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)
Review Article
Behaviors of Human T cells in SARS-CoV-2 Infection: Lessons and Tips

Ali Shams; Sahar Khosravi; Aysan Zareiye; Yeganeh Lalehzari; Reyhane Nematollahi; Solmaz Basti

Volume 20, Issue 4 , December 2023, Pages 382-399

https://doi.org/10.22034/iji.2023.98326.2567

Abstract
  Cell-mediated immunity (CMI) is crucial in controlling the highly aggressive and progressive SARS-CoV-2 infection. Despite extensive researches on severe COVID-19 infection, the etiology and/or mechanisms of lymphopenia, decreased T cell-mediated responses in patients, cytokine release storms (CRS), ...  Read More

Original Article
Antibody Production after COVID-19 Vaccination in Patients with Inborn Errors of Immunity

Maryam Nourizadeh; Elham Feizabadi; Milad Mirmoghtadaei; Ashraf Mohammadi; Mohammad Reza Fazlollahi; Leila Moradi; Zahra Pourpak

Volume 20, Issue 4 , December 2023, Pages 400-409

https://doi.org/10.22034/iji.2023.97759.2525

Abstract
  Background: Few studies have evaluated COVID-19 vaccine efficacy in patients with inborn errors of immunity (IEI).Objective: To evaluate the levels of antibody (Ab) production and function after COVID-19 vaccination in IEI patients with phagocytic, complement, and Ab deficiencies and their comparison ...  Read More

Original Article
Harnessing the Power of CAR-NK Cells: A Promising Off-the-Shelf Therapeutic Strategy for CD38-Positive Malignancies

Maryam Asadi; Razie Kiani; Vahid Razban; Seyed Nooreddin Faraji; Amirhossein Ahmadi; Jafar Fallahi; Amin Ramezani; Nasrollah Erfani

Volume 20, Issue 4 , December 2023, Pages 410-426

https://doi.org/10.22034/iji.2023.100424.2691

Abstract
  Background: CD38 is highly expressed on multiple myeloma (MM) cells and has been successfully targeted by different target therapy methods. This molecule is a critical prognostic marker in both diffuse large B-cell lymphoma and chronic lymphocytic leukemia.Objective: We have designed and generated an ...  Read More

Original Article
Relationship between TIM3 Expression on Peripheral T Lymphocytes and Post-Stroke Depression

Qifen Mao; Peng Zhang; Weicui Qi; Yueping Xia; Tingting Chen; Xiaofang Li; Songquan Xu; Zhiqiang Zhong; Zuifei Shangguan

Volume 20, Issue 4 , December 2023, Pages 427-437

https://doi.org/10.22034/iji.2023.98917.2598

Abstract
  Background: T cell immunoglobulin and mucin domain-containing protein 3 (TIM3) is a regulatory molecule expressed on a variety of cell types, including CD3+ T cells. Few studies have been conducted to look into the correlation between TIM3 expression on peripheral T lymphocytes and post-stroke depression ...  Read More

Original Article
Evaluation of mRNA Expressions of TOX and NR4As in CD8+ T cells in Acute Leukemia

Maryam Mohammadi; Hossein Asgarian-Omran; Behnam Najafi; Ahmad Najafi; Reza Valadan; Hossein Karami; Mohammad Naderisoraki; Maryam Alizadeforutan; Ramin Shekarriz; Mohsen Tehrani

Volume 20, Issue 4 , December 2023, Pages 438-445

https://doi.org/10.22034/iji.2023.97902.2537

Abstract
  Background: Thymocyte selection-associated high mobility group box protein (TOX) and members of the nuclear receptor 4A (NR4A) are known as transcription factors involved in T cell exhaustion.Objective: To evaluate the mRNA expression of TOX and NR4A1-3 in CD8+ T cells in acute leukemia.Methods: Blood ...  Read More

Original Article
Human Umbilical Cord Mesenchymal Stem Cells and their Extracellular Vesicles Modulate Pro- and Anti-inflammatory Cytokines in Ligature-induced Periodontitis

Xixi Wang

Volume 20, Issue 4 , December 2023, Pages 446-455

https://doi.org/10.22034/iji.2023.100211.2683

Abstract
  Background: Periodontitis is a chronic inflammatory condition that affects the tissues supporting the teeth, ultimately leading to tooth loss. Mesenchymal stem cells (MSCs) and their extracellular vesicles (EVs) play a crucial role in periodontitis by modulating the activities of gum cells and the immune ...  Read More

Original Article
High-free Fatty Acid Treatment Induced Anti-inflammatory Changes in a Natural Killer (NK) Cell Line

Hong Wu; Yanqi Fu; Yuhuan Jiang; Yali Liu; Zhibin Cheng; Yanting Shao; Yijun Nie

Volume 20, Issue 4 , December 2023, Pages 456-465

https://doi.org/10.22034/iji.2023.99972.2670

Abstract
  Background: Natural killer (NK) cells play a role in the pathogenesis of various metabolic diseases related to obesity. While our initial findings have indicated a potential involvement of NK cells in the pathogenesis of type 2 diabetes mellitus, the precise mechanism underlying NK cell-mediated development ...  Read More

Case Report
Rescue of HLH with T and B Lymphocyte Involvement Due to Epstein-Barr Virus by PD-1 Inhibitor/Ruxolitinib and Rituximab Combination Regimens: A Case Report

Miao Zhu; Jun Zhang; Qingqing Shi; Xing Sun; Haibo Wang; Mei Sun; Yanqing Liu

Volume 20, Issue 4 , December 2023, Pages 466-472

https://doi.org/10.22034/iji.2023.99254.2629

Abstract
  Hemophagocytic lymphohistiocytosis (HLH) is a fatal clinical syndrome. The most common cause of secondary HLH is Epstein-Barr virus (EBV) infection. EBV-HLH is a common clinical disease with high mortality, easy relapse, and poor prognosis. Therefore, treating EBV-HLH with T and B lymphocyte involvement ...  Read More