Volume 19 (2022)
Volume 18 (2021)
Volume 17 (2020)
Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)
1. Effects of Interleukin-10 -1082G/A and -592C/A Gene Polymorphisms on the Risk of Human Immunodeficiency Virus-1 Infection: An Updated Meta-analysis

Zhi-Hui Wang; Yue Wu; Zi-Wei Dai; Yuan-Yuan Dong; Bin Wang

Volume 19, Issue 1 , Winter 2022, , Pages 91-101


  This paper has aimed to review the available evidence on the association between Interleukin (IL) -10 -1082G/A, -592C/A gene polymorphisms and the risk of human immunodeficiency virus-1(HIV-1) infection. The data of PubMed updated in May 2021 were retrieved. The HIV infection risks were estimated in ...  Read More

2. Interleukin-10 Promoter and the CCR5 Polymorphisms in Iranian Azari Population with Multiple Sclerosis

Mohammad Asgharzadeh; Davoud Sanajou; Hossein Samadi Kafil; Mehdi Farhoudi; Daryoush Savadi Oskouei; Fatemeh Khaki-Khatibi; Fatemeh Ahmadi; Manouchehr Fadaee; Ali Vegari; Vahid Asgharzadeh; Jalil Rashedi; Behroz Mahdavi Poor; Pourya Gholizadeh

Volume 18, Issue 3 , Summer 2021, , Pages 241-248


  Background: Changes in the expression of cytokines as the result of the single nucleotide polymorphisms (SNPs), can affect the incidence of multiple sclerosis (MS). Objective: To investigate the relationship between the frequencies of interleukin-10 (IL-10)-1082 A/G (rs1800896) and CCR5-delta32 genotypes ...  Read More

3. Variants in Intron 4 of PD-1 Gene are Associated with the Susceptibility to SLE in an Iranian Population

Yousef Khanjari; Morteza Oladnabi; Nafiseh Abdollahi; Ahmad Heidari; Saeed Mohammadi; Alijan Tabarraei

Volume 17, Issue 3 , Summer 2020, , Pages 204-214


  Background: Programmed cell death protein 1 (PD-1) is a negative costimulatory molecule with immunomodulatory properties. Recently, PD-1 gene defects have attracted attention in the pathogenesis of SLE. Objective: Here, we assessed the association of PD-1 gene polymorphisms in intron 4 and haplotypes ...  Read More

4. Association of Human Leukocyte Antigens Class I & II with Graves’ Disease in Iranian Population

Zahra Mehraji; Ali Farazmand; Alireza Esteghamati; Sina Noshad; Maryam Sadr; Somayeh Amirzargar; Mir Saeed Yekaninejad; Aliakbar Amirzargar

Volume 14, Issue 3 , Summer 2017, , Pages 223-230

  Background: Graves’ disease (GD), a highly rampant autoimmune disorder of the thyroid gland, is responsible for 60-80% of the clinical cases of hyperthyroidism. Over the past decades, genetic association studies have identified several GD susceptibility loci in CTLA-4, TSHR and major histocompatibility ...  Read More

5. Combination of Myelin Basic Protein Gene Polymorphisms with HLA-DRB1*1501 in Iranian Patients with Multiple Sclerosis

Parham Nejati; Marzieh Attar; Maryam Rahimian; Davood Fathi; Majid Shahbazi

Volume 14, Issue 3 , Summer 2017, , Pages 231-239

  Background: Multiple sclerosis (MS), as a multifactorial autoimmune disease with complex genetic basis, causes demyelination in the central nervous system via cytokine responses to myelin antigens. Myelin basic protein (MBP) is the main protein component of the myelin sheath. HLA-DRB (human leukocyte ...  Read More

6. Clinical Relevance of Cytokines Gene Polymorphisms and Protein Levels in Gingival Cervical Fluid from Chronic Periodontitis Patients

Vamsi Lavu; Vettriselvi Venkatesan; Priyanka Venugopal; Bhaskar Venkata Kameswara Subrahmanya Lakkakula; Solomon Franklin Durairaj Paul; Kumarasamy Peria; Suresh Ranga Rao

Volume 14, Issue 1 , Winter 2017, , Pages 51-58

  Background: Cytokines are suggested to play a role in periodontitis. Objective: To determine and compare the levels of Interleukin-1 beta (IL-1β) and Tumor necrosis factor alpha (TNF-α) in gingival crevicular fluid (GCF) samples amongst healthy individuals and  those with chronic periodontitis. ...  Read More

7. Interleukin-23 Receptor Gene Variants in Acute Lymphoblastic Leukemia and Their Relation to Prognostic Factors

Mohammadrasul Zareinejad; Afshin Samiei; Behnaz Valibeigi; Tahereh Gholami; Soheila Zareifar; Zahra Amirghofran

Volume 14, Issue 1 , Winter 2017, , Pages 59-72

  Background: Interleukin (IL)-23 has an important role in tumor immune regulation. Objective: To investigate the possible association of interleukin-23 receptor (IL23R) gene variants rs1884444, rs10889677 and rs11209026 with development of acute lymphoblastic leukemia (ALL). Methods: The IL23R variants ...  Read More

8. Investigating the Association of IL-17A and IL-17F with Susceptibility to Pre-eclampsia in Iranian Women

Fahimah Anvari; Feryal Dabagh-Gorjani; Mohammad-Sadegh SoltaniZangbar; Eskandar Kamali-Sarvestani; Zahra Malek-Hosseini; Behrouz Gharesi-Fard

Volume 12, Issue 2 , Spring 2015, , Pages 117-128

  Background: Pre-eclampsia (PE) is one of the most important and life-threatening pregnancy disorders that affect at least 3-5% of all pregnancies. Imbalance in helper T cell functions may play a role in predisposing to PE or severity of the disease. Elevated frequencies of Th17 cells in the peripheral ...  Read More

9. Interleukin-8 but Not Interleukin-6 Variant May Affect Susceptibility to Brucellosis

Sadaf Asaei; Manoochehr Rasouli; Ali Moravej

Volume 10, Issue 3 , Summer 2013, , Pages 158-166

  Background: Increased levels of interleukin-8 (IL-8) and interleukin-6 (IL-6) in acute human brucellosis have been reported. Previous studies have shown that the production and level of IL-6 and IL-8 cytokines are associated with the polymorphism of the encoding genes. Objective: To investigate the probable ...  Read More

10. CCL22 16C/A Genetic Variation is not Associated with Breast Carcinoma in Southern Iranian Population

Nasrollah Erfani; Faezeh Moghaddasi-Sani; Mahboubeh Razmkhah; Mohammad Reza Haghshenas; Abdolrasoul Talaei; Abbas Ghaderi

Volume 9, Issue 4 , Autumn 2012, , Pages 226-233

  Background: CCL22/MDC is a CC chemokine with a critical role in regulation of the immune balance in physiological condition. CCL22/CCR-4 ligation has been documented to participate in the migration of regulatory T (Treg) cells and Th2 lymphocytes to the site of breast tumors; circumstances that are known ...  Read More

11. Strong Association of CTLA-4 Variation (CT60A/G) and CTLA-4 Haplotypes with Predisposition of Iranians to Head and Neck Cancer

Nasrollah Erfani; Mohammad Reza Haghshenas; Mohammad Ali Hoseini; Seyed Basi Hashemi; Bijan Khademi; Abbas Ghaderi

Volume 9, Issue 3 , Summer 2012, , Pages 188-198

  Background: Variations in Cytotoxic T Lymphocyte Antigen-4 (CTLA-4) affect the expression and function of this protein. Objective: We aimed to investigate the association of +49 A/G (rs231775), +1822 C/T (rs231779) and +6230 A/G (CT60, rs3087243) genetic variations, as well as the merged haplotypes in ...  Read More

12. CTLA4 Gene Variants in Autoimmunity and Cancer: a Comparative Review

Abbas Ghaderi

Volume 8, Issue 3 , Summer 2011, , Pages 127-149

  Gene association studies are less appealing in cancer compared to autoimmune diseases. Complexity, heterogeneity, variation in histological types, age at onset, short survival, and acute versus chronic conditions are cancer related factors which are different from an organ specific autoimmune disease, ...  Read More

13. Stromal Cell Derived Factor-1 Genetic Variation at Locus 801 in Patients with Myasthenia Gravis

Gholam ALi Yousefipour; Mohammad Reza Haghshenas; Sara Yahyazadeh; Nasrollah Erfani

Volume 8, Issue 2 , Spring 2011, , Pages 90-95

  Background: Myasthenia gravis (MG) is the most common disorder of neuromuscular junction in which autoantibodies develop against nicotinic acetylcholine receptor for unknown reasons. The association of immunomodulator genes with different autoimmune disease has been studied in recent years. Objective: ...  Read More

14. IL-1β (+3953 C/T) and IL-8 (-251 A/T) Gene Polymorphisms in H. pylori Mediated Gastric Disorders

Shohreh Farshad; Manoochehr Rasouli; Akram Jamshidzadeh; Ayda Hosseinkhani; Aziz Japoni; Abdolvahab Alborzi; Alireza Taghavi; Hossein Kazemi Asl; Reza Ranjbar

Volume 7, Issue 2 , Spring 2010, , Pages 96-108

  Background: Previous studies imply that IL-1 and IL-8 gene variations may play a crucial role in the genetic predisposition to different gastric disorders upon H. pylori infection. Objective: The aim of this study was to determine the potential association between the prevalence of certain polymorphic ...  Read More

15. Association of Myeloperoxidase -463 G/A Polymorphism with Clinical Outcome of Helicobacter Pylori infection in Iranian Patients with Gastrointestinal Diseases

Eskandar Kamali-Sarvestani; Hadi Farsiani; Michel Shamoon Pour; Abdulah Bazargani; Kamran Lankarani; Ali-Reza Taghavi; Mehdi Saberifiroozi

Volume 4, Issue 3 , Autumn 2007, , Pages 155-160

  Background: Polymorphisms in the immune related genes are important in the clinical outcome of Helicobacter pylori infection. Myeloperoxidase -463 G/A polymorphism has been shown to reduce enzyme expression and activity. Objective: the aim of the present study is to investigate the association of myeloperoxidase ...  Read More

16. Killer Cell Immunoglobulin-Like Receptors Influence the Innate and Adaptive Immune Responses

Raja Rajalingam

Volume 4, Issue 2 , Spring 2007, , Pages 61-78

  Natural killer (NK) cells are a subset of lymphocytes which play a crucial role in early innate immune response against infection and tumor transformation. Furthermore, they secrete interferon-γ (IFN-γ) and tumor necrosis factor (TNF) prompting adaptive immu-nity. NK cells distinguish the ...  Read More

17. Investigation of FcγRIIA and FcγRIIIA Polymorphism in Multiple Sclerosis: A Case Control Study

Alireza Nikseresht; Mohammad Ali Azizi; Behrouz Gharesi-Fard; Eskandar Kamali Sarvestani

Volume 3, Issue 3 , Summer 2006, , Pages 136-141

  Background: Multiple Sclerosis (MS), the most common demyelinating disease of the CNS, is immunologically mediated in genetically susceptible individuals. Receptors for the Fc fragment of IgG (FcγR) might induce inflammatory responses through linking the humoral and cellular immune responses by ...  Read More

18. Interleukin-10 Promoter Polymorphisms and Breast Cancer Risk in Iranian Women

Hossein Abdolrahim-Zadeh; Niloufar Hakkakian; Reza Asadollahi; Behrouz Gharesifard; Jamal Sarvari; Eskandar Kamali-Sarvestani; Abdolrasoul Talei

Volume 2, Issue 3 , Summer 2005, , Pages 158-165

  Background: IL-10 is an anti-inflammatory cytokine which is involved in tumorigenesis. Over production of IL-10 and elevated number of IL-10 generating mononuclear cells in breast tumor tissue has already been shown. Objective: To determine the association of IL-10 promoter polymorphisms with increased ...  Read More

19. Lack of Association between ctla-4 A49G Polymorphism and Vitiligo

Mohammad Javad Fattahi; Abdul Mohammad Pezeshki; Maryam Emad; Mohammad Hosein Lohrasb; Azra Shamseddin; Abbas Ghaderi; Mehrnoosh Doroudchi

Volume 2, Issue 2 , Spring 2005, , Pages 97-102

  Background: Vitiligo is an acquired skin disorder that selectively destroys melanocytes in epidermis with an unknown etiology.   Objective: To investigate the exon 1 A49G polymorphism of cytotoxic T lymphocyte antigen-4 (ctla-4) gene in vitiligo patients.   Methods: The A49G polymorphism was ...  Read More

20. Cytokines Genes Polymorphisms in Iranian Patients with Pulmonary Tuberculosis

Ali Akbar Amirzargar; Abdol Ali Danesh; Farideh Khosravi; Mohammad Hossein Niknam; Behrouz Nikbin

Volume 1, Issue 2 , Summer 2004, , Pages 125-129

  Background: Pulmonary tuberculosis (PTB) has recently become a major problem in developed countries especially in immune compromised HIV infected individuals. Cytokines, their genes and receptors have been implicated in the protective immunity, pathophysiology and development of tuberculosis.   ...  Read More

21. Association of IFN-¹ Gene Polymorphism with Type 1 Diabetes in Iranian Patients

Ali Rafinejad; Mohammad Hossein Niknam; Ali Akbar Amirzargar; Farideh Khosravi; Forouzan Karimi; Bagher Larijani

Volume 1, Issue 2 , Summer 2004, , Pages 130-132

  Background: Type 1 Diabetes (T1D) is a chronic and progressive autoimmune disorder. Cytokines play a critical role in the pathogenesis of T1D.   Objective: IFN-¹ polymorphism was investigated in T1D and compared with normal controls.   Methods: Thirty patients suffering from T1D and 40 ...  Read More