Volume 17 (2020)
Volume 16 (2019)
Volume 15 (2018)
Volume 14 (2017)
Volume 13 (2016)
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)
1. Hemozoin Enhances Maturation of Murine Bone Marrow Derived Macrophages and Myeloid Dendritic Cells

Shahid Waseem; Kashif-Ur-Rehman -; Ramesh Kumar; Tariq Mahmood

Volume 13, Issue 1 , Winter 2016, , Pages 1-8

  Background: Falciparum malaria is a severe health burden worldwide. Antigen presenting cells are reported to be affected by erythrocytic stage of the parasite. Malarial hemozoin (HZ), a metabolite of malaria parasite, has adjuvant properties and may play a role in the induction of immune response against ...  Read More

2. Induction of T Regulatory Subsets from Naïve CD4+ T Cells after Exposure to Breast Cancer Adipose Derived Stem Cells

Mahboobeh Razmkhah; Nadieh Abedi; Ahmad Hosseini; Mohammad Taghi Imani; Abdol-Rasoul Talei; Abbas Ghaderi

Volume 12, Issue 1 , Winter 2015, , Pages 1-15

  Background: Adipose derived stem cells (ASCs) provoke the accumulation and expansion of regulatory T cells, leading to the modulation of immune responses in tumor microenvironment. Objective: To assess the effect of tumoral ASCs on the trend of regulatory T cells differentiation. Methods: Peripheral ...  Read More

3. Islet Amyloid Polypeptide is not a Target Antigen for CD8+ T-Cells in Type 2 Diabetes

Fathollah Kalantar; Mohammad Hossein Dabbaghmanesh; Emanuela Martinuzzi; Mohsen Moghadami; Zahra Amirghofran

Volume 11, Issue 1 , Winter 2014, , Pages 1-12

  Background: Type 2 diabetes (T2D) is a chronic metabolic disorder in which beta-cells are destroyed. The islet amyloid polypeptide (IAPP) produced by beta-cells has been reported to influence beta-cell destruction. Objective: To evaluate if IAPP can act as an autoantigen and therefore, to see if CD8 ...  Read More

4. Association between HLA-DQB1*03:01 and Bullous Pemphigoid in Iranian Patients

Nafiseh Esmaili; Hossein Mortazavi; Sheyda Chams-Davatchi; Maryam Daneshpazhoooh; Maede Rayati Damavandi; Zeinab Aryanian; Ali Akbar Amirzargar

Volume 10, Issue 1 , Winter 2013, , Pages 1-9

  Background: A common Human Leukocyte Antigen (HLA) class II allele, DQβ1*03:01, seems to be associated with Bullous pemphigoid (BP) in Caucasians whereas previous studies in other ethnic groups showed other HLA class II alleles as genetic predisposing factors for BP. Objective: To investigate the ...  Read More

5. Protein Profiling of the Secretome of FcεRI Activated RBL-2H3.1 Cells

Esmaeil Sadroddiny; Jafar Ai; Kathleen Carroll; Trong Khoa Pham; Phillip Wright; Ashutosh Pathak; Birgit Helm

Volume 9, Issue 1 , Winter 2012, , Pages 1-31

  Background: Secretory proteins of IgE receptor activated mast cells and basophils play a pivotal role in the generation of immediate and long term immune responses in allergy and type I hypersensitivity. Objective: The present study aims to generate a 2-D map and profile of proteins secreted from a high ...  Read More

6. Expression of Chemokine Receptors on Th1/Th2 CD4+ Lymphocytes in Patients with Multiple Sclerosis

Alireza Andalib; Hassan Doulabi; Mohammadreza Najafi; Mehdi Tazhibi

Volume 8, Issue 1 , Winter 2011, , Pages 1-10

  Background: Th1 cells preferentially express CXCR3, CCR5 and CCR6, while CCR3 and CCR4 are predominantly expressed by Th2 cell subsets. Multiple Sclerosis (MS) is a Th1 cell-dependant chronic inflammatory disease of the central nervous system, and immunomudolatory cytokines could alter the chemokine ...  Read More

7. Molecular Cloning and Expression of Human Gamma Interferon (IFN-g) Full cDNA in Chinese Hamster Ovary (CHO) Cells

Alireza Zamani; Jalil Tavakkol Afshari; Mohammad Yousef Alikhani

Volume 3, Issue 1 , Winter 2006, , Pages 1-8

  Background: IFN-g is mostly secreted by activated CD4+ , CD8+ T cells and NK cells. This cytokine has immunomodulatory, anti-cancer and anti-microbial effects and is important for prophylaxis, diagnosis and treatment of chronic infections and cancers. Objective: The purpose of this study was to clone ...  Read More

8. Comparison of Two Flow Cytometric Methods for Detection of Human Invariant Natural Killer T Cells (iNKT)

Mohammad Fereidouni; Farhzad Jabbari Azad; Mahmoud Mahmoudi; Abdolreza Varasteh; Reza Farid Hosseini

Volume 7, Issue 1 , Winter 2010, , Pages 1-7

  Background: Invariant natural killer cells (iNKT) are an important immunoregulatory T cell subset. Currently several flow cytometry-based approaches exist for the identifi-cation of iNKT cells, which rely on using the 6B11 monoclonal antibody or a combina-tion of anti-Vα24 and anti-Vβ11 antibodies. ...  Read More

9. Interleukin-17A and Interleukin-17F mRNA Expressions in Peripheral Blood Mononuclear Cells of Patients with Multiple Sclerosis

Zohreh Babaloo; Farhad Babaie; Mehdi Farhoodi; Mohammadreza Aliparasti; Behzad Baradaran; Shohreh Almasi; Ahmad Hosseini

Volume 7, Issue 4 , Autumn 2010, , Pages 1-1

  Bakground: Multiple sclerosis (MS) is a CD4+ T cell-mediated autoimmune disease affecting the central nervous system (CNS). It was previously believed that Th1 cells were pathogenic T cells in experimental autoimmune encephalomyelitis (EAE). However, the functional role of Th1 cells in EAE has been reconsidered ...  Read More

10. The Efficiency of CD40 Down Regulation by siRNA and Antisense ODN: Comparison of Lipofectamine and FuGENE6

Padideh Ebadi; Mohammad Hossein Karimi; Ali Akbar Pourfathollah; Saheb Ghadam Lotfi; Zahra Soheila Soheili; Shahram Samiee; Smerdis Hajati; Fatemeh Nadali; Bita Geramizadeh; Seyyed Mohammad Moazzeni

Volume 6, Issue 1 , Winter 2009, , Pages 1-11

  Background: Dendritic cells (DCs) are ideal accessory cells in the field of gene therapy. Delivery of DNA and siRNA into mammalian cells is a useful technique in treating various diseases caused by single gene defects. Selective gene silencing by small interfering RNAs (siRNAs) and antisense oligodeoxynucleotides ...  Read More

11. Recent Progress in Allergen Immunotherapy

Kayhan T Nouri-Aria

Volume 5, Issue 1 , Winter 2008, , Pages 1-24

  The efficacy of allergen immunotherapy for the treatment of allergic rhinoconjunctivitis with or without seasonal bronchial asthma and anaphylaxis caused by the sting of the hymenoptera class of insects has been clearly demonstrated in numerous well-designed, placebo-controlled trials. Immunotherapy ...  Read More

12. Dendritic Cells in Transplant Tolerance

Mahyar Nouri-Shirazi

Volume 4, Issue 1 , Winter 2007, , Pages 1-14

  Dendritic cells (DCs) are a heterogeneous family of professional APCs involved in priming adaptive immune responses. Donor DCs (direct pathway of allorecognition) and recipient DCs presenting processed donor major histocompatibility complex (MHC) as peptides (indirect pathway of allorecognition) participate ...  Read More

13. The Effect of Monophosphoryl Lipid A on Maturation of DCs from Patients with Acute Myeloid Leukaemia

Noha Mohamed El Husseiny; Walaa Abd El Fattah Attya Elkak; Mervat Said El Ansary; Engy Mohamed Abd El Aziz El Khateeb; Mervat Wagih Mattar; Doaa Mohamed El Demerdash

Volume 14, Issue 1 , Winter 2017, , Pages 1-12

  Background: Generation of monocyte-derived dendritic cells (MDDC) is induced in the presence of GM-CSF and IL-4, and a maturation stimulus is added to the monocyte culture to obtain mature Dendritic Cells (DCs) suitable for therapy. TNF-α is the most common cytokine used for activating DCs and ...  Read More

14. The Significance of B-cell Subsets in Patients with Unclassified Hypogammaglobulinemia and Association with Intravenous Immunoglobulin Replacement Requirement

Sait Karaman; Semiha Bahçeci Erdem; Nesrin Gülez; Ferah Genel

Volume 15, Issue 1 , Winter 2018, , Pages 1-13

  Background: Patients with unclassified hypogammaglobulinemia (UCH) constitute a diagnostic and therapeutic dilemma, because information concerning the clinical and immunological characteristics of these patients is insufficient. Objective: To evaluate B-cell subsets in cases with UCH and common variable ...  Read More

16. Th1/Th2 Imbalance and Elevated PD-L1 in Pleural Effusion Predict the Risk of Multi-Drug Resistant Tuberculous Pleuritis

Hongyan Xu; Yueqing Yang; Qianhong Wu; Yan Zhang

Volume 17, Issue 1 , Winter 2020, , Pages 1-13


  Background: Patient immune status might be indicative of the variance in bacterial genetics in drug-resistant tuberculous pleuritis and could be used for predicting the risk of multi-drug resistant tuberculous pleuritis (MDR-TB). Objective: To determine the significance of Th2/Th1 ratio and concentration ...  Read More

17. Monoclonal Antibodies as Therapeutic Agents: Advances and Challenges

Helmout Modjtahedi

Volume 2, Issue 1 , Winter 2005, , Pages 3-20

  Despite the major advances in conventional forms of treatment (i.e. surgical techniques, radiotherapy and chemotherapy) and improved survival rates, cancer is still the second leading cause of death in developing countries. One major limitation of cytotoxic drugs and radiation in the treatment of cancer ...  Read More

18. Immunological Basis of Neurological Diseases

Mojtaba Zarei

Volume 1, Issue 1 , Spring 2004, , Pages 6-25

  Clinical neurology has been traditionally considered as an academic speciality in which the specialist regurgitates his/her knowledge of neurology without being able to do much for the patient. This attitude is no longer acceptable. Surge of information and discoveries in neurosciences within the last ...  Read More

19. Expression of CXC Chemokines Gro/KC and SDF-1a in Rat H4 Hepatoma Cells in Response to Different Stimuli

Gholamhossein Hassanshahi; Mohammad Kazemi Arababadi; Alan James Dickson

Volume 3, Issue 2 , Spring 2006, , Pages 54-60

  Background: It is now well established that several environmental stress factors cause activation of p38 MAP kinase and JNK in various cell types to produce chemokines. Objective: To investigate the expression of CXC chemokines Gro/KC and SDF- 1a in rat's H4 hepatoma cells in response to heat shock, ...  Read More

20. The Effect of Beta Interferon on Dendritic Cells and Cytokine Synthesis by CD4+ T Cells

Saeid Abediankenari; Davoud Shaker; Farshideh Abedian; Arazmohammad Mirabi

Volume 6, Issue 2 , Spring 2009, , Pages 61-66

  Background: Dendritic cells (DC) are a key regulator of the immune response, and interferon- beta (IFN-β) is considered an immunomodulatory molecule for DC. Objective: The purpose of this study was to evaluate the ability of IFN-β treated DC to induce cytokine secretion by CD4+ T cells. Methods: ...  Read More

21. Killer Cell Immunoglobulin-Like Receptors Influence the Innate and Adaptive Immune Responses

Raja Rajalingam

Volume 4, Issue 2 , Spring 2007, , Pages 61-78

  Natural killer (NK) cells are a subset of lymphocytes which play a crucial role in early innate immune response against infection and tumor transformation. Furthermore, they secrete interferon-γ (IFN-γ) and tumor necrosis factor (TNF) prompting adaptive immu-nity. NK cells distinguish the ...  Read More

22. Detection of IL-20R1 and IL-20R2 mRNA in C57BL/6 Mice Astroglial Cells and Brain Cortex Following LPS Stimulation

Bahareh Abd Nikfarjam; Massoumeh Ebtekar; Farzaneh Sabouni; Zahra Pourpak; Maryam Kheirandish

Volume 10, Issue 2 , Spring 2013, , Pages 62-69

  Background: Astrocytes, which comprise ~90% of overall brain mass, are involved in brain immunity. These cells represent the non-professional class of CNS-resident APCs and may promote or inhibit CNS inflammation depending on the cytokines they secrete. IL-10 family of cytokines and their receptors, ...  Read More

24. CTL Responses to DCs Stimulated with Leishmania Antigens Detected by DCs Expressing Leishmania gp63

Hossein Rezvan; Ali Khodadadi; Selman Ali

Volume 11, Issue 2 , Spring 2014, , Pages 65-73

  Background: Leishmania is a pathogenic parasite which infects mononuclear cells in vertebrate hosts. Different strategies have been taken to develop immunity against Leishmania . DCs loaded with immunogenic antigen have resulted in different levels of Th1-type immune response and cytotoxic T lymphocytes ...  Read More

25. Strong Immune Responses Induced by a DNA Vaccine Containing HPV16 Truncated E7 C-terminal Linked to HSP70 Gene

Zahra Meshkat; Hoorieh Soleimanjahi; Hessam Mirshahabi; Mojtaba Meshkat; Maryam Kheiandish; Zuhair Mohammad Hassan

Volume 8, Issue 2 , Spring 2011, , Pages 65-75

  Background: Vaccines capable of controlling tumor virus based infections are found difficult to develop due to the consistence latent infection in the host. DNA vaccines are attractive tools for the development of HPV vaccines and inducing antigen-specific immunity owing to the stability, simplicity ...  Read More